SerumScoop: Tips, tricks and news
Canities is the fancy word for premature greying of the hair, and most people have some amount of greying, from very sparse, to fairly widespread.
The color, density, and styling of hair have a colossal bearing on one’s self-esteem, especially in today’s times where a person’s first impression may turn out to his or her last impression. However, increased longevity of human life means that we spend an increasing proportion of our lives sporting signs of aging on our scalp. The most dramatic age-related change in hair is the onset of hair graying or canities, which is the gradual age-dependent dilution of hair color to gray or white, also known assenile canities (canities (L.), canus, hoary, gray). The graying of hair occurs due to an admixture of normally pigmented, hypomelanotic, and amelanotic melanosomes. White hair is the endpoint of graying. The age of onset of senile canities appears to be genetically controlled and inheritable. The average age for Caucasians is mid-30s; for Asians, late-30s; and for Africans, mid-40s. A good rule of thumb is that by 50 years of age, 50% of people have 50% gray hair. 
The darker the hair color, the more noticeable early graying will be. Particular hair colors are associated with some ethnic groups. The Fischer–Saller scale, named after Eugen Fischer and Karl Saller, is used to determine the shades of hair color [Table 2].  Majority of the human population (80–90%) fall into the U to Y category (dark brown/black hair) of this scale.
WHAT HAPPENS DURING PHYSIOLOGICAL AGING (CANITIES)?
The type of hair fiber keeps on changing with age. Neonates... have unpigmented lanugo hair while adults have short (mostly pigmented) vellus hair or fine pigmented intermediate hair and long terminal hair shafts. Similarly, surface morphology also shows variation with age, particularly with the reduction in the cuticular scale size. The synthetic capacity of hair bulb melanocytes is maximum during youth. An average scalp hair follicle usually receives 7 ± 15 melanocyte replacements from an outer root sheath reservoir to the hair bulb, which occurs in the first 45 years preceding the onset of gray hair. Different theories have been suggested for the age-related gradual loss of pigmentation. This includes exhaustion of enzymes involved in melanogenesis, impaired deoxyribonucleic acid (DNA) synthesis, loss of telomerase, loss of antioxidant mechanisms, and anti-apoptotic signals. Table 3 shows various changes that take place in a white hair bulb during canities. The net result is that fewer melanosomes are incorporated into cortical keratinocytes of the hair shaft. Cessation of pigment production by melanocytes in the hair matrix area surrounding the dermal papilla is a slow process resulting in slow outgrowth of graying hair at the pace of normal hair growth. All hair bulbs do not decrease pigment incorporation in the growing hair at the same time giving “salt and pepper pattern”to the scalp hair.
It has been observed that hair graying pattern depends on gender, age of onset, and smoking habits, with smokers having higher chances of having canities. Temporal area is involved in males first while in females, it is the frontal area. Age of onset also affects the area of involvement; parietal and occipital areas are involved in patients of young age while frontal area is involved in late onset group.
WHY DOES PREMATURE CANITIES OCCUR?
Premature canities is a common cause of referral to dermatologists. It occurs most commonly without any underlying pathology, but is said to be inherited in an autosomal dominant manner. It is different from poliosis which is circumscribed hypomelanosis of hair. The diseases associated with poliosis are given in Table 4. The pathogenesis of premature canities has not yet been clearly elucidated. A hypothesis that pH and cysteine level of melanosomes play critical roles in determining the course of mixed melanosomes leading to dark, light, or red hair phenotype has been proposed because of the diversity of human hair pigmentation. The role of pH in controlling mixed melanogenesis has attracted much attention as it is seen that tyrosinase activity is progressively suspended by lowering the pH, with a shift to more pheomelanin phenotype.[8-11] Concentration of cysteine in melanosomesis another control point in mixed melanogenesis. Chemical hair straightening is done by alkaline disruption of the disulphide bonds in the cortex of the hair shaft. It causes considerable damage to the hair because of the pH (9–12) of the chemicals leaving the hair dry and fragile. In a questionnaire-based study, Shetty et al. reported that 22% of the cases experienced graying of hair also.[8,12] There is definitely a role of trace metal ions in hair pigmentation. Copper ions are required by tyrosinase at its active center; thus, it is likely that copper ions in melanocytes are necessary to maintain normal color. Fatemi Naieni et al. compared the mean copper concentration in patients with PHG and controls and found lower mean serum copper concentration in the cases.
Data suggest that oxidative stress can also play a major role in the premature aging of skin and hair. This theory has been widely accepted these days. Reactive oxygen species (ROS) or free radicals, generated by a variety of internal and environmental factors may result in direct damage to various cellular structural membranes, lipids, proteins, and DNA. To combat these free radicals, our body has endogenous defense mechanisms such as antioxidative enzymes which include superoxide dismutase, catalase, glutathione peroxidase as well as non-enzymatic antioxidative molecules like vitamin E, vitamin C, glutathione, and ubiquinone. The production of these endogenous defense mechanisms decreases while that of free radical increases, resulting in aging.
APPROACH TO MANAGEMENT OF PREMATURE CANITIES
...Recent experimental work indicates that cinnamidopropyltrimonium chloride, a quaternized UV absorber, delivered from a shampoo system, is suitable for photo protection of hair, while simultaneously providing an additional conditional benefit on hair, Solid lipid nanoparticles have been developed as novel carriers of UV blockers for use on skin and hair, offering photoprotection on their own too by reacting and scattering ultraviolet radiation (UVR).[ 24]
Recent advances in the management of aging hair and scalp are anti-aging compounds. Shampoos are largely ineffective as anti-aging agents due to water dilution and short contact time, and antioxidants such as vitamin C and E in these preparations protect fatty substances in the shampoo from oxidation, and not the hair.
— Portions excerpted from Sehrawat M, Sinha S, Meena N, Sharma PK. Biology of hair pigmentation and its role in premature canities. Pigment Int 2017;4:7-12.
HERE'S A NEW SOLUTION TO PREMATURE CANITIES
New RevivHair REV with Grey Hair Reverse and Hair Stimulation is a novel leave-in serum that targets greying hair three different ways, all without the use of colorants and dyes.
It's one of the first products to combine award-winning new ingredients Greyverse and Darnkenyl to address both the appearance of grey and thinning hair:
Beauty, fashion, and shopping site NYMPHASHION reviews stellar Ultimate Serum:
"…I can honestly tell it’s one of the most effective anti-age serums I’ve tried in the last year."
Ultimate Serum with Stem Cells, Growth Factors, and Peptides compares to TNS Essential Serum by SkinMedica®. Ultimate Serum contains 23 of the same ingredients in TNS, and also includes hexapeptides. It's also twice the size, and about half the price!
Read more here:
FIRST US SKINCARE PRODUCT WITH AWARD-WINNING NEUROPHROLINE ACTIVE COSMETIC INGREDIENT
SAN FRANCISCO CA USA, OCT 13, 2016 (PRNewswire): RevivSerums.com, a San Francisco-based global leader in cosmetic chemistry innovation, introduces a first-of-its-kind cosmetic topical, HA7X Multi-Molecular Hydrator Serum.
HA7X is one of the first products of its kind to include award-winning Neurophroline™ active cosmetic ingredient from the Active Beauty business unit of Givaudan, a group of companies headquartered in Switzerland. Neurophroline cosmetic ingredient won in-cosmetics 2016 Gold Award for Best Ingredient at its annual global showcase for personal care ingredients in Paris this spring.
A multi-dimensional approach to the application of topical hyaluronic and rejuvenating complexes, this first-of-its-kind dermo-biotech serum combines seven forms of hyaluronic technologies with the Neurophroline ingredient to deliver visible hydration, protection, plumping, smoothing, rejuvenation, and recovery from the skin's surface down to subcutaneous levels.
HA7X supports the skin’s natural ability to replenish its own scaffolding, tightening and cushioning, and targets the protection of skin from stressors like cortisol, pollution and UV.
“HA7X is another great example of innovative cosmetic chemistry from Reviv Serums,” said Maya Waldman, Director of Happiness for Reviv Serums. "There is clear demand for a product that addresses the target concerns: hydration, scaffolding, and the negative effects of stress and pollution, at a fair price. Our customers will love that this new serum also contains both instant-plumping, as well as timed-release components.”
HA7X includes 29 of the primary ingredients in the industry leading HA5 Rejuvenating Hydrator® by SkinMedica® / Allergan®. HA7X then includes two additional, new hyaluronic technologies (for a total of seven). Yet with these new actives, HA7X is about half the price as the SkinMedica product.
The Neurophroline ingredient is found in an exclusive and sustainable phyto extract, and is a unique bioactive cosmetic ingredient able to block the production of cortisol, the major stress hormone, by skin cells. It has also shown to promote the release of endorphins, a natural calming neuropeptide acting on mood and promoting a sense of well-being and relaxation.
The Neurophroline ingredient shows fast benefits in only 2 weeks, with a visible reduction of redness (up to 2.4x), a very fast recovery of skin luminosity (+57%), and improvement in global skin color (+99%) after only 28 days.
Environmental pollutants including cigarette smoke, ozone, exhaust fumes and heavy metals generate free radicals that induce oxidative damage and put skin cells in a state of stress. Givaudan’s active ingredient Neurophroline targets these sources and effects, which contributes to reducing the appearance of premature aging caused by environmental pollution.
"As we continue to build our premier global brand in award-winning personal care ingredients, we are excited about launching Neurophroline on the US market, winning the innovation award, and contributing to all of our customers’ success. We highly value Reviv’s commitment to formulating innovation into their products,” noted Romain Lemeunier, head of Givaudan Active Beauty North America. “The future looks very bright for skincare science, and skincare consumers.”
HA7X also contains several novel deepsea bioactives which target skin renewal and reactivity, and microspheres that impart an elegant silky texture and optical blurring effect.
HA7X Serum debuts at an introductory price of $89 for a limited time here. It is available immediately at RevivSerums.com, which ships to many countries worldwide with free shipping, and at select retailers, e-tailers, salons, medspas and physician's offices.
RevivSerums.com is a wholly owned component of Astonishing Developments Ltd. based in San Francisco, a global leader in topical therapies for hair, scalp, lashes, face, neck and body.
HA7X is a trademark of Astonishing Developments Ltd. Other company and/or product names may be trade names, trademarks and/or registered trademarks of the respective owners with which they are associated. Astonishing Developments Ltd. and its RevivSerums.com products, including its HA7X Multi-Molecular Hydrator Serum product, are neither affiliated with, nor approved by, Allergan Inc., nor SkinMedica®. These statements have not been evaluated by the U.S. Food and Drug Administration. Products not intended to diagnose, treat, cure, or prevent any disease.
#HA7X #skincare #Neurophroline #skinhydration #skinstressors #incosmetics
The skin on the back of your hands is often exposed to UV sun damage, and it can be especially evident since the skin is thinner there. Age spots, seborrheic keratosis, and even precancerous lesions can occur over time.
Here are some tricks to prevent and even reverse such sun damage:
Obviously, always wear broad spectrum sunscreen on your hands. That's a given. Realize that washing your hands will often wash off sunscreen and so will rubbing/use that occurs throughout the day, so reapply often when you know you'll be in the sun. When that's not possible, try only washing the palm side of your hands. That's the area that needs washing the most anyway.
Gloves work well too of course, especially if you're laboring outside. Be sure to choose a pair that does not have mesh, so that your hands are good and covered.
To help reverse the damage that's already occurred, use our Phloretin Serum with Ferulic and Alpha Lipoic Acid. It can work wonders on age spots and help create taunt, clear, healthy skin everywhere including your hands.
Ultimate Serum is the first direct competitor to award-winning TNS Essential Serum® (NEWBEAUTY™ Beauty Choice Award Winner and InStyle™ Beauty Award Winner) by SkinMedica® which is now owned by Allergan, Inc. The patent on the TNS product relates to the medium called NouriCel-MD®, a "proprietary blend" of growth factors. We at Reviv Serums outflank this patent by simply providing our growth factors in a different conditioned media. In addition to the growth factors, we also include 42 of the top primary ingredients in TNS Essential Serum, and leapfrog by adding two of cosmetic chemistry's latest ingredients: stem cells and hexapeptides.
With our latest version of Ultimate Serum, we've added 10+ primary actives from SkinMedica's "upgrade" to TNS Essential Serum, TNS® Advanced +.
Ultimate Serum is 70% larger than either TNS product (50 mL / 1.69 FL OZ vs. 1.0 OZ) and yet is just about a third of the cost of TNS Essential Serum's hefty price of $281.00 and TNS Advanced Plus' $295.00.
It’s the ultimate rejuvenator in a single serum. Navigate to its product page here.