Ultimate Serum - now with exosomes!
![](https://cdn.gethypervisual.com/images/shopify/fccfe64e-0369-409a-a7c5-47a95370a8d5/1725_Ultimate_Serum_callout_icons.jpg)
✔ COMPARE TO TNS ADVANCED+
AND TNS ESSENTIAL SERUM
NEW AND IMPROVED
COMBINED actives of TNS Essential Serum
AND TNS Advanced+
Microbiome probiotics
More growth factors cytokines
More peptides
Amino acids
Same low price
WITH GROWTH FACTORS, PHYTO STEM CELLS, PEPTIDES, AND PROBIOTICS
NOW WITH EXOSOMES
Ultimate Serum is a novel next-generation high performance product that addresses every concern of aging skin and is the ultimate rejuvenator in a single serum. With RevivAdvancedMedia™ exosomes, growth factors cytokines, stem cells & peptides, polypeptides, probiotics, tripeptides, hexapeptides, skin bioactives, antioxidants, emollients, sebum-controllers, anti-inflammatories, and collagen producers.
Containing 12+ of the same top ingredients in award-winning TNS® Advanced+ by SkinMedica® Allergan®, and other great actives from its predecessor TNS Essential Serum® , Ultimate Serum leapfrogs such products by including revolutionary biotechnology that helps protect skin stem cells. Topped off with microbiome probiotics, SYN®-TC peptides, amino acids, and the matrix-fibroblast stimulation power of hexapeptides.
Bonus facts: Over 70% larger than the ounce-size of TNS, our Ultimate Serum is dramatically less than TNS's $295 hefty MSRP. Here's a head-to-head comparison.
ABOUT THE KEY INGREDIENTS
REVIV EXOSOMES
Introducing a revolutionary scientific concept in skincare innovation - groundbreaking exosomes. This precious material used to be impossible to garner, and extraordinarily expensive. Recent technological advances make it possible to provide this material in a commercial skincare product.
Our exosomes are tiny but mighty extracellular vesicles derived from bone marrow stem cells, and they work at the cellular level, rejuvenating and revitalizing your skin from within. Exosomes are not live cells (they are "acellular") and do not carry any active DNA. Consider them the "words" between cells. A unique biofiltration process ensures that no intact living cells or DNA is included in the exosome; only the most "pluripotent" kind of growth factors, cytokines, and proteins that signal a basic "rejuvenate" command to skin. They act as vital messengers, playing a primary role in skin rejuvenation. Exosomes directly help to activate and revive skin cells, and support cell communication by exchanging proteins such as keratin and fibroblasts between cells, encouraging skin repair and regeneration.
Our exosomes and conditioned media are ethically derived from healthy vetted adult female paid volunteers.
RevivAdvancedMedia™
RevivAdvancedMedia growth factors & cytokines are natural substances made to maintain healthy skin. They support the repair of damaged skin, make components that provide firmness & elasticity while helping to maintain skin’s protective functions. Aging skin makes fewer growth factors than cells in youthful skin. RevivFibroMedia contains Fibroblast, Keratinocyte, Epidermal, and Vascular Endothelial Growth Factors, among other such factors, cytokines, and matrix proteins produced from Stem Cell Conditioned Media.
Overall, RevivAdvancedMedia helps dramatically improve the appearance of fine lines, wrinkles, skin tone and texture.
RevivUltimateFunctionals™
Our latest version of remarkable Ultimate Serum contains the same 12+ actives from SkinMedica's upgrade to TNS, TNS® Advanced+. These potent actives include Progeline™ (Trifluoroacetyl Tripeptide-2), Prolixir S20™ (Dimer Tripeptide-43), Vitis Vinifera (Grape) Flower stem cells, and Chlorella Vulgaris Extract, among others. The very latest in cosmetic chemistry for skin rejuvenation. With this latest upgrade to Ultimate Serum, we've eliminated Whey Protein & Seracin (making the serum fully vegan and gluten-free), and removed dimethicone, shea, and olive components which some consumers dislike.
While TNS Advanced+ dropped some of the great actives from TNS Essential Serum, like CoQ10/Ubiquinone and Vitamin C, we've kept plenty of the great ingredients from both, and combined them into a single powerhouse serum.
PHYTOCELLTEC MALUS DOMESTICA
PhytoCellTec™ is a revolutionary liposomal preparation from Switzerland based on the stem cells of a rare Swiss apple - the Uttwiler Spatlauber - known for its excellent storability and thus its longevity. A novel technology enables the stem cell cultivation of this rare and endangered species. Various studies demonstrate its age-delaying and anti-wrinkle effects.
PEPTIDES
Hexapeptide-51 Amide and the triple peptides in SYN®-TC, are all novel short-chain amino acids with skin regenerative properties, and clinical studies show proven wrinkle reduction. Progeline™ targets progerin, an aging biomarker. Matrixyl™ 3000 and Prolixir S20™ are patented peptides targeting cell senescence. Prolixir S20 also targets the Ubiquitin-Proteasome (Ub-P) system and sustained proteasome efficacy with less protein damage.
ALPHA ARBUTIN
A glycoside extracted from the bearberry plant, arbutin is also found in wheat and pear skins. As a pigment inhibitor, It inhibits the visible effects of tyrosinase, helping to thwart the appearance of age spots, melasma and mottled complexion.
DIPALMITOYL HYDROXYPROLINE (SEPILIFT™ DPHP)
This Ecocert validated ingredient is a superb overall anti-aging active which also works to moisturize while providing a triple firming action: collagen fiber contraction, protection of dermal supporting tissue and anti-radical action.
BV-OSC (TETRAHEXYLDECYL ASCORBATE)
This oil-soluble version of vitamin C is very bio-available and has excellent percutaneous absorption into the skin compared to ascorbic acid. It is able to penetrate keratinocytes to assist with the prevention of UV damage and provide a cytoprotection effect. Studies show its anti-aging properties. It has also been shown to reduce the appearance of melanogenesis and tyrosinase activity by more than 80%, making it an excellent ingredient for brightening and evening out skin tone.
SACCAROMYCES FERMENT LYSATE FILTRATE
This innovative ingredient offers DNA protection, lipid barrier protection and repair, free radical protection, and protection of antioxidants. In vitro studies confirm it prevents the formation of Advanced Glycation Endproducts (AGEs) and stimulates the appearance of soluble elastin (precursor to insoluble elastin).
ANTIOXIDANTS
Ergothioneine / Thiotaine, Ubiquinone / Coenzyme Q10, Tocopheryl Acetate, and Tocotrienols are all powerful antioxidants which effectively break peroxide chain reactions, prevent free radicals, and reduce the appearance of inflammation. Ergothioneine is an especially good DNA repair molecule.
MICROBIOME PROBIOTICS
A concentrate of probiotic Lactobacillus Lysate, from the bacteria found naturally in yogurt, targets the skin's microbiome (the balance of good and bad bacteria) and helps re-balance, renew, and optimize skin health. Our lysate (not live bacteria) is isolated from soy and chicory, and is non-animal derived and non-dairy.
BONUS INGREDIENT: TEN AMINO ACIDS
Amino acids are the building blocks of both peptides and proteins, and each has a specific role in skin care. Amino acids maintain skin's hydration, texture, resilience, and an overall supple, healthy appearance.
HUMECTANTS & MOISTURIZERS
Sodium PCA and Pentavitin 72-hour moisture active all contribute to supple, superbly moisturized skin without occlusiveness.
Compatible with most complimentary topicals like retinols, tretinoin, vitamin C, copper peptide, etc. Avoid simultaneous application of very low-pH exfoliating products. Compatible with cosmetic-strength dermarolling / microneedling. Suitable for the under-eye area as well as the upper eyelid orbital bone area, but avoid direct contact with eyes. If contact occurs, rinse eyes thoroughly with water. Decrease frequency or discontinue use if irritation develops. For external use only. The product does not need refrigeration, and can be kept at room temperature without compromising potency or efficacy.
Note from our legal eagles: Reviv Serums Ultimate Serum is neither endorsed, nor sponsored by, nor affiliated with Allergan, Inc., an AbbVie company. None of our products are intended for use in the cure, mitigation, treatment or prevention of disease and/or are not intended to affect the structure or any function of the human body. Any testimonials on this website are based on individual results, and do not constitute a guarantee that you will achieve the same results.
Slide off the smoke-colored overcap, and twist the pump from "STOP" to "OPEN". Press on the center of the pump to dispense. Apply a thin layer to clean, dry skin (face, neck, chest & hands) once or twice daily. Twist the pump back to "STOP" and replace the overcap.
Compatible with most complimentary topicals like retinols, tretinoin, vitamin C, copper peptide, etc. Avoid simultaneous application of very low-pH exfoliating products. Suitable for the upper eyelid orbital bone area, but avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water. Decrease frequency or discontinue use if irritation develops. For external use only.
The Ultimate Serum bottle is an "airless" style container with a piston that pushes product to the top by vacuum pressure. On occasion, such containers need "priming." To do that, turn the container upside down and tap the top end of the bottle into the palm of your opposite hand a few times, briskly. This will cause the piston/plate to move up a bit. Then test the dispenser by pressing it once or twice until product dispenses. We generally recommend this technique be applied occasionally if necessary.
FULL INGREDIENTS (1.69 FL OZ / 50 ML):
Water/Aqua/Eau, Pentylene Glycol, * RevivAdvancedMedia, Human Fibroblast Derived Stem Cell Conditioned Media, Glycereth-7 Triacetate, Ethoxydiglycol, Lactococcus Ferment Lysate, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, ** RevivUltimateFunctionals, Dextran, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
* RevivAdvancedMedia:
Hamamelis Virginiana Extract, Glycerin, Methylsulfonylmethane (MSM), Human (Bone Marrow Derived) Mesenchymal Stem Cell Exosomes, Alpha-Arbutin, Palmitoyl Tripeptide-5, Ergothioneine, Dipalmitoyl Hydroxyproline, Ubiquinone, Saccharomyces Ferment Lysate Filtrate, Tetrahexyldecyl Ascorbate, rH-Oligopeptide-1 [Epidermal Growth Factor] & rh-Polypeptide-3 [Keratinocyte Growth Factor] & sh-Polypeptide-9 [Vascular Endothelial Growth Factor] & sh-Polypeptide-1 [Basic Fibroblast Growth Factor] & sh-Polypeptide-11 [Acidic Fibroblast Growth Factor].
** RevivUltimateFunctionals:
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Nannochloropsis Oculata (micro algae) Extract, Centella Asiatica (Organic Gotu Kola) Extract, Chondrus Crispus Extract, Equisetum Arvense (Horsetail) Extract, Geranium Maculatum (Wild Geranium) Extract, Taraxacum Officinale (Organic Dandelion) Root Extract, Achillea Millefolium (Yarrow) Flower Extract, Curcuma Longa Rhizome (Tumeric) Callus Extract, Spirulina Platensis Extract, Aloe Barbadensis Leaf (Organic Aloe) Juice, Cassia Angustifolia Seed Polysaccharide, Simmondsia Chinensis (Organic Jojoba) Seed Oil, Arginine, Aspartic Acid, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, PCA, Sodium PCA, Sodium Lactate, Sodium Chloride, Carbomer, Alcohol (organic), Hydroxyethylcellulose, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate.
After clicking on a datasheet to view it, click Back in your browser to return to this product page.
PhytoCellTec Malus Domestica video: