SerumScoop: Tips, tricks and news

All About Keratinocyte Growth Factor (KFG)

A primary active in our RevivHair Stimulating Serum and RevivLash Lash & Brow Stimulating Serum: Keratinocyte Growth Factor (KGF or rh-Polypeptide-3). Numerous scientific/clinical studies show how KGF helps promote hair growth. Check out these published articles:

Danilenko, Dimitry M.; Ring, Brian D.; Yanagihara, Donna; Benson, William; Wiemann, Bernadette; Starnes, Charles O.; Pierce, Glenn F. (1995). Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. American Journal of Pathology 147: 145-54.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869891/pdf/amjpathol00043-0151.pdf

Richardson GD; Bazzi H; Fantauzzo KA; Waters JM; Crawford H; Hynd P; Christiano AM; Jahoda CA. (2009). KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.
http://www.ncbi.nlm.nih.gov/pubmed/19474150

Karvinen, S; Pasonen-Seppanen, S; Hyttinen, JM; Pienimaki, JP; Torronen, K; Jokela, TA; Tammi, MI; Tammi, R (2003) Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan syntheses 2 and 3. J Biol Chem, 278:49495-49504
http://www.ncbi.nlm.nih.gov/pubmed/14506240

Braun S; Krampert M; Bodó E; Kümin A; Born-Berclaz C; Paus R; Werner S. (2006) Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents Journal Cell Science, 119: 4841-4849
http://www.ncbi.nlm.nih.gov/pubmed/17090603

Jang, JH (2005) Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2). Biotechnology Letters, 27:749-52.
http://www.ncbi.nlm.nih.gov/pubmed/16086254

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5 Methods For Stopping Hair Loss (and Possibly Even Growing Some Back)

Man in front of barbershop

If you’re balding, it’s a lot harder to grow all your hair back than it is to stop your follicles from disappearing in the first place. Slow the erosion of your hairline with these five dermatologist-approved strategies.

1. Meditation and Exercise

In balding men, periods of rapid shedding are often brought on by stress. The reason? Stress floods your body with the hormone cortisol, and then other hormone levels fluctuate in response, says Melissa Piliang, M.D., a hair-loss expert at Cleveland Clinic.

If you’re predisposed to balding, this can speed the process. To better control your stress, you might want to try traditional meditation or, if that’s not your thing, an active meditation regimen such as yoga or tai chi.

Or just commit to getting in better shape.

A 2015 study in PLOS One found that older men with a high level of cardio respiratory fitness release 42 percent less cortisol throughout the day than unfit men do. The stress hormone has been linked to all sorts of diseases.


2. Minoxidil

Minoxidil (Rogaine) probably won’t restore what’s lost, but it can help you hold on to what’s left and even help you regrow a bit. The topical med increases bloodflow as well as oxygen and nutrient delivery to the follicle.

Liquid Rogaine can cause irritation and leave a greasy coating on your hair, so opt for the 5 percent foam, says Dr. Piliang.

Rogaine costs only $29.99 a month (rogaine.com), but you’ll have to use it forever to retain any gains. [Note that solubilizers required to dissolve minoxidil are known irritants.]

Rub it into your scalp in the morning and again at night for the most benefit. Bonus: Unlike the oral medication finasteride (the other FDA-approved drug, sold as Propecia), minoxidil isn’t linked with erectile dysfunction or decreased libido.


3. Laser Devices

Besides minoxidil and finasteride, laser devices are the only other hair-loss treatment cleared by the FDA in recent years. The devices are sold as wands or Star Wars-worthy helmets for $200 to nearly $900.

In the largest study, published in 2014 in the American Journal of Clinical Dermatology, men who zapped their scalp three times a week saw a significant increase in hair density after 26 weeks.

One theory is that lasers have an antioxidant effect on hair follicles. But before you rush out to buy a six-pack of combs, understand that “hair growth” doesn’t necessarily mean “hair other people can see.”

You will likely feel it, though, which may have a placebo effect on your confidence.

4. Ketoconazole Shampoo

Swap your standard shampoo for a brand with 1 percent ketoconazole, such as Nizoral ($13 for 7 ounces, drugstore.com). Or ask your doctor to prescribe the 2 percent version.

“It’s marketed as an antidandruff ingredient, but there’s solid research ketoconazole is an anti-androgen,” says Dr. Piliang.

Anti-androgens block the conversion of testosterone to D•HT, the signaling molecule that shrinks hair follicles.

That’s how finasteride works too, but because ketoconazole is confined to the scalp, it doesn’t have the risk of negative sexual side effects, she says.

Massage the shampoo into your scalp, step out of the shower stream, wait 2 to 3 minutes, and rinse.

5. Vitamin D

A British Journal of Dermatology study reported that people with alopecia areata, an autoimmune disorder that causes hair loss, were three times as likely to be D deficient as those with healthy hair. “Vitamin D helps hair reset its growth phase,” explains Dr. Piliang.

To jumpstart your follicles, she recommends taking 2,000 IU a day of vitamin D3, especially in winter when you’re exposed to less sunlight.

But don’t try baking your bald spot in the sun to ramp up your vitamin D production. That might result in an even bigger problem.

“Men should be careful about sun exposure on a balding scalp, since it’s a common location for skin cancers,” Dr. Piliang warns.

— Reprinted / excerpted from Men's Health Magazine



We would of course add a recommendation: the remarkable RevivHair™ line of stimulating products. Proven RevivHair Max Stimulating Serum, transforming RevivScalp Rejuvenating Scalp Serum Masque, and RevivHair Stimulating Shampoo & Conditioner.  Boost your results 2 to 4 times a year with RevivHair Placode Booster Serum. The RevivHair line provides a full compliment of the latest in cosmetic chemistry to help boost the appearance of thicker, denser, stronger, healthier hair.


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All about CRESSATINE® in RevivScalp™ and how it can help encourage hair growth


CRESSATINE is a primary component of our RevivScalp Rejuvenating Scalp Serum Masque. CRESSATINE is a novel aqueous extract of watercress (Nasturtium officinale) and Indian cress (Tropaeolum majus) leaves and shoots, stabilized with plant glycerin, and is ECOCERT qualified.

Excerpts from its specification documentation, prepared by its manufacturer, France-based Solabia:

Titrated with sulfur, CRESSATINE is designed to facilitate hair growth and strengthen hairs from the root: 

- by providing the elements (sulfur and other minerals) needed to produce keratin for solid, well-structured hair.
- by helping initiate hair regrowth via the Wnt pathway.
- by stimulating keratinocyte differentiation via the KGFs (keratinocyte growth factors) released when the Wnt/β-catenin pathway is activated.
- by prolonging the growth phase using the Wnt pathway and KGFs.

ACTIVATION OF WNT/ ß-CATENIN SIGNALING PATHWAY

CRESSATINE was shown to boost the activation of WNT / ß-CATENIN signaling pathway by 37% vs. control:



CRESSATINE chart boost of Wnt / β-catenin pathway, regeneration and growth of hair



STIMULATION OF KGF PRODUCTION

CRESSATINE® significantly stimulates KGF production, by 107% vs. control, and in a dose-dependent manner, which in turn stimulates the keratinocytes, causes a well- structured hair to be produced, and lengthens the anagen phase:

CRESSATINE in RevivScalp boosts KGF causes a well-structured hair to be produced, lengthens anagen phase

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RevivSerums Launches Another Cosmetic Breakthrough: RevivLash™ with Redensyl

SAN FRANCISCO, NOV. 20, 2014 (PRNEWSWIRE): Today RevivSerums introduces RevivLash, a revolutionary lash and brow restoration formula designed to give users thick, lush eyelashes and eyebrows. RevivLash is the first product of its kind to include award-winning Redensyl from Switzerland-based Induchem AG.

Redensyl won in-Cosmetics 2014 Silver Award for Best Personal Care Ingredient this spring.

"We're delighted to add this new formula to our repertoire, and expect our customers will be delighted with the results: lush, thicker lashes & brows without breaking the bank," said Jeff Havard, Director of Operations for RevivSerums.com.

The product combines two patented Induchem molecules - DHQG and EGCG2. These target hair follicle stems cells, reactivating the proliferation of stem cells.

Designed for both women and men, this next-generation leave-in serum can significantly help boost lash and brow length, thickness, strength and overall health.

Tester Christen Smith of Orange County CA noted, "I couldn't be more impressed with this product. I saw new eyelashes begin to bud after just a few applications. I love the price point too, especially in comparison to the famous Allergan physician-only product."

In addition to the incorporation of Redensyl, RevivLash contains several other remarkably effective actives: Keratinocyte Growth Factor (rh-Polypeptide-3), Myristoyl Pentapeptide-17 and Octapeptide-3.

In a 60-day, 28-person consumer study of RevivSerums' new formula, 97% of testers said their eyelashes appeared longer or fuller, and 88% of respondents who applied the product to their brows said their eyebrows appeared thicker or fuller.

“RevivSerums.com is a great example of a company with an enthusiastic, creative culture and strong team delivering unique, on-trend products with compelling value. We are pleased to contribute to their further success and insatiable innovations with our cutting edge ingredients,” said Parand Salmassinia, General Manager of Induchem's U.S.A. division.

RevivLash is specifically formulated to reduce potential for the irritation that occurs with other eyelash restoration products. Unlike Allergan's lash enhancer, and products like LiLash(R), RevivLash contains no prostaglandin analogues, and is a cosmetic that can be purchased by consumers without having to obtain a prescription.

The new serum, a $100 value, debuts today for only $49 for a limited time. Its release coincides with Cosmetica Berlin, the definitive autumn beauty trade event in Europe. RevivLash is available immediately at RevivSerums.com, which ships to most countries worldwide, and at select retailers, salons, medspas and physician's offices.

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About RevivSerums.com RevivSerums.com is a wholly owned component of Astonishing Developments Ltd., based in San Francisco. The company specializes in novel and innovative clinical treatment serums for skin and hair rejuvenation.

Legal RevivSerums and RevivLash are trademarks of Astonishing Developments Ltd. Redensyl is a registered trademark of Induchem Holding AG Corporation, Switzerland. Other company and/or product names may be trade names, trademarks and/or registered trademarks of the respective owners with which they are associated.

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Head To Head Comparison: Ultimate Serum™ vs. SkinMedica® TNS Essential Serum®

Ultimate Serum "Compare To" product to TNS Essential Serum from SkinMedica | Larger, Cheaper, 23 same ingredients

Ultimate Serum
is the first direct competitor to award-winning TNS Essential Serum® (NEWBEAUTY™ Beauty Choice Award Winner and InStyle™ Beauty Award Winner) by SkinMedica® which is now owned by Allergan, Inc. The patent on the TNS product relates to the medium called NouriCel-MD®, a "proprietary blend" of growth factors. We at Reviv Serums outflank this patent by simply providing our growth factors in a different conditioned media. In addition to the growth factors, we also include 42 of the top primary ingredients in TNS Essential Serum, and leapfrog by adding two of cosmetic chemistry's latest ingredients: stem cells and hexapeptides.

Regarding the percentage of growth factors in each product: In actuality, the growth factors in both products are quantities measured in micrograms. TNS just lists "conditioned media" as the first ingredient, and does not break down the quantities of the actual factors like EGF, KGF, VEGF, IGF, TGF, etc. Growth factors are signaling molecules, therefore very little volume/quantity is required to be active and effective (they are measured in micrograms, one millionth of a gram). Like a spark plug, a little bit will go a very long way, and more that the recommended quantity is not "better." As for the other non growth factor primary ingredients, they're the same - plus we add the PhytoCellTec® Stem Cells, hexapeptides, SYN-TC peptides, and microbiome probiotic technology. Ultimate Serum is 70% larger than TNS (50 mL / 1.69 FL OZ vs. 1.0 OZ) and yet is less than half TNS's hefty price of $281.00.

Ultimate Serum contains a safe Ecocert preservative — Optiphen Plus.

Ultimate Serum is really 11 different products in one:

 

• A brightening product
• An antioxidant serum
• A firming and tightening product
• An anti-inflammatory
• A peptide serum
• A green tea complex product
• A vitamin C serum
• A sebum controller
• A collagen stimulator serum
• A growth factor serum
• A moisturizer and light emollient

 

It’s the ultimate rejuvenator in a single serum. Navigate to its product page here.

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