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Making Hair Loss History: Native Polyphenols to Kick-start Hair Regrowth

Written By: The Serum Guru

Treating alopecia with RevivHair Hair Stimulating Serum & Redensyl

A new study of the patented molecules in our Redensyl® ingredient confirm its remarkable role in hair stimulation and hairloss prevention. 

Redensyl is not the only ingredient that makes RevivHair Hair Stimulating Serum so remarkably effective — our novel growth factors, stem cells, and peptides combine to make it a powerhouse. But Redensyl is undoubtedly a big hero in our hero serum.
Excerpts from the study:

Results: Clinical Studies

It is well-known that the growth of scalp hair is a cyclical process, made up of successive phases of growth (anagen) and rest (telogen).11, 20 In a non-balding scalp, more than 90% of scalp hair is in an anagen phase.12

However, with AGA [Androgenic Alopecia] , the progressive shortening of the anagen phase, as well as an increase in the duration of the lag phase (i.e., the interval between the shedding of a telogen hair and the emergence of a replacement anagen hair), across successive hair cycles, progressively decreases the percentage of hair follicles in the anagen phase. For men with male pattern hair loss, only 60% to 80% of total hairs are in anagen phase. This shortening of the anagen phase leads to progressive miniaturization of hair follicles, which contributes to a decrease of visible hair over affected areas of the scalp.13

In the present clinical study, the authors demonstrated that treatment with DEGZ [Redensyl] 3% for three months daily efficiently treats androgenetic alopecia by increasing the percentage of hair in the anagen phase (by about +9%) and decreasing the percentage of hair in telogen phase (by about -17%) (see Table 1). In this study, an insignificant placebo effect also was observed, likely due to the mechanical activation of microcirculation, with almost no more evolution after one month.

None of the results obtained with the placebo were statistically significant. However, 3% DEGZ increased the density ratio of hair in the anagen phase to hair in the telogen phase. After three months, the ratio reached 2.37 (+29%) while the placebo showed no evolution after one month (see Table 2). Furthermore, this hair density increase observed after three months of treatment was confirmed by the scalp’s macrophotography (see Figure 6).

At the end of the study, volunteers using the test DEGZ formula judged their hair as stronger and thicker (data not shown). These benefits are likely provided by the glycine and zinc in the test blend. Glycine is an essential component for the hair shaft structure that directly enters hair’s composition of keratin-associated protein.14 Zinc reinforces hair shaft structure and is essential for cystin incorporation into keratin.15

Conclusion

DHQG and EGCG2 are two glucosylated derivatives of native dihydroquercetin and epigallocatechin gallate. These two polyphenols were previously shown to have different properties for hair care.7, 16

The present studies demonstrate that when these two molecules are used alone or in combination, beneficial properties are observed; including HFDPc metabolism stimulation, ORSc proliferation, beta catenin activation and anti-apoptotic effects on ORSc. In combination with EGCG2, and glycine and zinc, DHQG also induced the growth of AGA hair follicle explants cultured in vitro according to the Philpott model. This study also confirmed the crucial role of EGCG2 in hair growth induction.

Clinical investigations described here show this blend can treat androgenic alopecia by re-launching hair growth pathways and visibly decreasing hair loss within three months by promoting the conversion of hair follicles into the anagen phase via the activation of Wnt/β-catenin pathway, and by limiting the apoptosis of ORSc. Finally, the efficiency of the test blend as an alopecia hair loss treatment was confirmed by a high user satisfaction rate (+71%) during the clinical investigation.

- See more at: http://www.cosmeticsandtoiletries.com/testing/efficacyclaims/Making-Hair-Loss-History-Native-Polyphenols-to-Kick-start-Hair-Regrowth-425945524.html


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