SerumScoop: Tips, tricks and news
Canities is the fancy word for premature greying of the hair, and most people have some amount of greying, from very sparse, to fairly widespread.
The color, density, and styling of hair have a colossal bearing on one’s self-esteem, especially in today’s times where a person’s first impression may turn out to his or her last impression. However, increased longevity of human life means that we spend an increasing proportion of our lives sporting signs of aging on our scalp. The most dramatic age-related change in hair is the onset of hair graying or canities, which is the gradual age-dependent dilution of hair color to gray or white, also known assenile canities (canities (L.), canus, hoary, gray). The graying of hair occurs due to an admixture of normally pigmented, hypomelanotic, and amelanotic melanosomes. White hair is the endpoint of graying. The age of onset of senile canities appears to be genetically controlled and inheritable. The average age for Caucasians is mid-30s; for Asians, late-30s; and for Africans, mid-40s. A good rule of thumb is that by 50 years of age, 50% of people have 50% gray hair. 
The darker the hair color, the more noticeable early graying will be. Particular hair colors are associated with some ethnic groups. The Fischer–Saller scale, named after Eugen Fischer and Karl Saller, is used to determine the shades of hair color [Table 2].  Majority of the human population (80–90%) fall into the U to Y category (dark brown/black hair) of this scale.
WHAT HAPPENS DURING PHYSIOLOGICAL AGING (CANITIES)?
The type of hair fiber keeps on changing with age. Neonates... have unpigmented lanugo hair while adults have short (mostly pigmented) vellus hair or fine pigmented intermediate hair and long terminal hair shafts. Similarly, surface morphology also shows variation with age, particularly with the reduction in the cuticular scale size. The synthetic capacity of hair bulb melanocytes is maximum during youth. An average scalp hair follicle usually receives 7 ± 15 melanocyte replacements from an outer root sheath reservoir to the hair bulb, which occurs in the first 45 years preceding the onset of gray hair. Different theories have been suggested for the age-related gradual loss of pigmentation. This includes exhaustion of enzymes involved in melanogenesis, impaired deoxyribonucleic acid (DNA) synthesis, loss of telomerase, loss of antioxidant mechanisms, and anti-apoptotic signals. Table 3 shows various changes that take place in a white hair bulb during canities. The net result is that fewer melanosomes are incorporated into cortical keratinocytes of the hair shaft. Cessation of pigment production by melanocytes in the hair matrix area surrounding the dermal papilla is a slow process resulting in slow outgrowth of graying hair at the pace of normal hair growth. All hair bulbs do not decrease pigment incorporation in the growing hair at the same time giving “salt and pepper pattern”to the scalp hair.
It has been observed that hair graying pattern depends on gender, age of onset, and smoking habits, with smokers having higher chances of having canities. Temporal area is involved in males first while in females, it is the frontal area. Age of onset also affects the area of involvement; parietal and occipital areas are involved in patients of young age while frontal area is involved in late onset group.
WHY DOES PREMATURE CANITIES OCCUR?
Premature canities is a common cause of referral to dermatologists. It occurs most commonly without any underlying pathology, but is said to be inherited in an autosomal dominant manner. It is different from poliosis which is circumscribed hypomelanosis of hair. The diseases associated with poliosis are given in Table 4. The pathogenesis of premature canities has not yet been clearly elucidated. A hypothesis that pH and cysteine level of melanosomes play critical roles in determining the course of mixed melanosomes leading to dark, light, or red hair phenotype has been proposed because of the diversity of human hair pigmentation. The role of pH in controlling mixed melanogenesis has attracted much attention as it is seen that tyrosinase activity is progressively suspended by lowering the pH, with a shift to more pheomelanin phenotype.[8-11] Concentration of cysteine in melanosomesis another control point in mixed melanogenesis. Chemical hair straightening is done by alkaline disruption of the disulphide bonds in the cortex of the hair shaft. It causes considerable damage to the hair because of the pH (9–12) of the chemicals leaving the hair dry and fragile. In a questionnaire-based study, Shetty et al. reported that 22% of the cases experienced graying of hair also.[8,12] There is definitely a role of trace metal ions in hair pigmentation. Copper ions are required by tyrosinase at its active center; thus, it is likely that copper ions in melanocytes are necessary to maintain normal color. Fatemi Naieni et al. compared the mean copper concentration in patients with PHG and controls and found lower mean serum copper concentration in the cases.
Data suggest that oxidative stress can also play a major role in the premature aging of skin and hair. This theory has been widely accepted these days. Reactive oxygen species (ROS) or free radicals, generated by a variety of internal and environmental factors may result in direct damage to various cellular structural membranes, lipids, proteins, and DNA. To combat these free radicals, our body has endogenous defense mechanisms such as antioxidative enzymes which include superoxide dismutase, catalase, glutathione peroxidase as well as non-enzymatic antioxidative molecules like vitamin E, vitamin C, glutathione, and ubiquinone. The production of these endogenous defense mechanisms decreases while that of free radical increases, resulting in aging.
APPROACH TO MANAGEMENT OF PREMATURE CANITIES
...Recent experimental work indicates that cinnamidopropyltrimonium chloride, a quaternized UV absorber, delivered from a shampoo system, is suitable for photo protection of hair, while simultaneously providing an additional conditional benefit on hair, Solid lipid nanoparticles have been developed as novel carriers of UV blockers for use on skin and hair, offering photoprotection on their own too by reacting and scattering ultraviolet radiation (UVR).[ 24]
Recent advances in the management of aging hair and scalp are anti-aging compounds. Shampoos are largely ineffective as anti-aging agents due to water dilution and short contact time, and antioxidants such as vitamin C and E in these preparations protect fatty substances in the shampoo from oxidation, and not the hair.
— Portions excerpted from Sehrawat M, Sinha S, Meena N, Sharma PK. Biology of hair pigmentation and its role in premature canities. Pigment Int 2017;4:7-12.
HERE'S A NEW SOLUTION TO PREMATURE CANITIES
New RevivHair REV with Grey Hair Reverse and Hair Stimulation is a novel leave-in serum that targets greying hair three different ways, all without the use of colorants and dyes.
It's one of the first products to combine award-winning new ingredients Greyverse and Darnkenyl to address both the appearance of grey and thinning hair:
GGB Rating: 5/5
ABOUT REVIVHAIR PLACODE BOOSTER SERUM:
This amazing leave-in serum is claimed to be a great addition to your haircare routine in order to reduce hair loss, encourage hair growth, and develop healthy hair follicles. Apart from this it also helps in strengthening the fibre against breakage and thickening the existing hair strands. Formulated with the most eligible hair growth peptides this serum can be used by men and women both.
REVIVHAIR PLACODE BOOSTER SERUM REVIEW:
RevivHair Placode Booster Serum comes in set of five glass vials with a syringe which can be used for applying the serum on to the scalp. The serum in the glass vial is tightly sealed and though it looks thick in texture it gets applied very well on to the scalp. Each vial consists of 6mL of serum, you need to use 1mL of serum every day. Using the syringe you can draw out exact 1mL of the serum and can apply it all over the scalp and massage it on to the scalp. The serum gets absorbed immediately and does not feel sticky or heavy. I preferred using it daily at night. If you are washing your hair daily, you can use it every morning after washing hair as well. It would be better to keep it as long as possible on to the scalp.
The best thing I observed about using this serum was that immediately within 2-3 uses my hairfall was reduced by 80 percent. Moreover I also observed better texture in my hair after using it for more than 2 weeks. About hair growth I observed that my hair partition did look much dense compared to what it was couple of weeks ago. RevivHair claims that the serum consists of highly stable and highly pure biometric peptides which is derived from bacterial fermentation which stimulates hair growth, thickening of hair and reducing hairfall.
I could genuinely see the difference in my hair density and texture. I would recommend this serum for anyone who is facing hairfall or hair thinning. Currently the product is available at discounted rate of USD 44.00/- and can be bought from here.
Full review here.
SUPER HAIR GROWTH JOURNAL: a beauty blogger's journey "I am so happy with the results!" — evaluation of RevivHair Stimulating Serum with Redensyl, Growth Factors, Peptides & Stem Cells.
She also evaluated RevivHair's Placode Booster Serum. "Literally, all my family that has hair loss has loved this RevivHair Placode Booster Serum."
Read more here:
Here's a list of the latest evaluations and reviews of RevivHair Placode Booster Serum from renowned beauty review sites, beauty bloggers & vloggers, and other compendium sites:
"…it’s definitely small hair growth. I started to get comments and questions at work about what I did differently with my hair. My hairline looks a lot fuller than it was and my husband agrees."
Kelly's Thoughts on Things
"Within two short weeks of using this product, I was able to notice smooth and unbelievable progress. My hair truly felt thicker and amazing, and the results were just out of this world. I plan on continuing to use the RevivHair Placode Booster Serum, and I even have my daughter using it as well!"
"I didn’t really notice any difference until after the first week or so, then it was almost like I had put fertilizer on my head…lol!"
Barbie's Beauty Bits
Tips and Tricks for Making Your Limp, Thinning Hair Thicker
"…right off hand I noticed my hair was much healthier looking and shiny. My hair is hardly ever shiny."
Letters To La La Land
life & style blog
"I have been using it for almost two weeks and have already noticed as steady progress with using the RevivHair Placode Booster Serum. I noticed a 'boost' in how my hair felt to touch and it did make my hair thicker."
#BeautyVlogger Country Girl Loves Makeup
"I am absolutely amazed at this product."
Simple Mom Reviews
Beauty & Product Reviews
"…overall I really like the product and feel that it made an improvement in my hair…"
Hanna Marie Lei
life & stuff
"After using just one bottle of the biomimetic oligopeptides in this RevivSerums set I can say I'm happy with the results so far. I've already seen noticeable results in thickness and it looks healthier."
I Am The Makeup Junkie
Beauty products review site
"Notice how the hair in front is now thicker and more lush. My hair grew very fast too. I like how well it looks. I was very happy with this product and would use it again."
Aging can take a heavy toll on the eyelashes, making them noticeably thinner, shorter, and more brittle. Many people resort to commercial products to create an illusion of improvement, but they fail to address the underlying causes.
Current treatments include drugs originally developed to treat glaucoma.1 The hefty price tag and side effects associated with these drugs prompted scientists to search for safer alternatives.2,3
In this article, you’ll learn how scientists uncovered natural compounds that work in complementary ways to protect and strengthen the structural foundation of eyelashes—naturally making them healthier, longer, and thicker.
Getting to the Root of Eyelash Growth
Stem cells are responsible for the constant self-renewal and repair of the skin. They have the unique ability to either remain a stem cell or transform into a specialized cell type through cell division.4 Research shows that stem cells reside at the base of each hair follicle where they facilitate hair regeneration.5 These are referred to as hair follicle stem cells.
Each eyelash follicle rotates through the same three stages of growth as other body hair follicles. The first stage (anagen) is the growth phase that lasts roughly one to two months.6 It is characterized by stem cells giving rise to specialized cells called keratinocytes with two main functions: 1) producing the hair shaft visible above the skin, and 2) synthesizing the tough and fibrous protein keratin that adds fullness, length, and strength to the hair shaft.7-9
As the eyelash follicle enters the second or transitional stage (catagen), which lasts approximately two weeks, it begins to shrink and hair growth ceases. In the third and final stage (telogen), the eyelash follicle becomes active once again, producing new hair that emerges from the skin’s surface by pushing out old hair to shed naturally. Telogen is the longest phase for eyelashes, lasting around four to nine months.6
As a person ages, exposure to ultraviolet (UV) radiation compromises the regenerative capacity of hair follicle stem cells.10 Keratin production also diminishes in hair follicles.11 Together, these age-associated changes lead to the outward appearance of weak, thin, and short eyelashes.
Fortunately, scientists have uncovered compounds that effectively target these changes to improve the appearance of eyelashes.
Novel Plant Extract Safeguards against Ultraviolet Radiation
Ultraviolet radiation induces oxidative stress in hair follicle stem cells that reduces their vitality and activity, in turn diminishing the health and longevity of the eyelashes.12,13 Scientists began investigating safe and effective compounds that protect hair follicle stem cells against the consequences of sun exposure. Plant stem cells derived from a rare grape variety quickly stood out.
Gamay Teinturier Fréaux grapes grow in an east-central region of France. They have red flesh and juice that signifies a high content of anthocyanins, flavonoids that combat oxidative stress through potent free radical scavenging activity.14,15 The unique synergy between anthocyanins and other metabolites present in the grape provides frontline defense against ultraviolet damage.16
The capacity of stem cells to form colonies, known as colony-forming efficiency, is a key measure of their vitality and activity. Ultraviolet radiation has been shown to decrease colony-forming efficiency. Researchers conducted a laboratory experiment in which skin stem cells were treated with or without grape stem cell extract before exposure to ultraviolet radiation. While untreated cells experienced a 58% decrease in colony-forming efficiency, no changes were seen in treated cells. This demonstrated that treated cells were safeguarded against harmful ultraviolet radiation.16
Let’s now take a look at how a recently developed peptide significantly enhances eyelash growth.
Myristoyl Pentapeptide-17 Stimulates Eyelash Growth
The formation of keratin in the anagen phase is essential for eyelash growth and density. With advancing age, this process fails to run smoothly.11 To combat age-related decline in keratin synthesis, scientists developed a peptide called myristoyl pentapeptide-17. It has been shown in laboratory experiments to increase the expression of keratin genes by up to 160%, thereby boosting keratin production.17 This has translated into striking results in human clinical studies.
In a recent trial, 15 human volunteers ranging in age from 24 to 82 applied an eyeliner serum containing myristoyl pentapeptide-17 to the roots of their lashes. The researchers used computer-assisted image analysis software to assess eyelash characteristics. They observed a 25% increase in eyelash length and thickness in just 14 days!17
Even more impressive, another study revealed that participants applying an eyeliner serum with myristoyl pentapeptide-17 to the target area increased eyelash thickness and length by 72% after six weeks. Both studies reported no adverse side effects.17
Glycoproteins Support Hair Follicle Formation
Glycoproteins are large molecules composed of carbohydrate and protein. They form a vital part of the extracellular matrix that provides a proper environment for the development of new hair follicles. In fact, research indicates that glycoproteins act as powerful chemical messengers between the layers of the skin to jumpstart eyelash growth.18,19
Panthenol Exerts Powerful Moisturizing Effects
Panthenol has been a mainstay ingredient in hair products for the past two decades and for good reason. It is a derivative of pantothenic acid (vitamin B5), a vital component of coenzyme A that assists in metabolic functions such as protein and lipid synthesis. Panthenol is converted into pantothenic acid in the hair shaft where it effectively binds water molecules, thereby improving eyelash moisture.20
Current treatments to improve aging eyelashes come with a steep price and substantial side effects, making them an unattractive option for many people. Fortunately, scientists have identified a network of complementary compounds, including a novel plant extract, myristoyl pentapeptide-17, glycoproteins, and panthenol, which protect and strengthen hair follicles to naturally deliver healthier, longer, and thicker eyelashes.
— Excerpted/reprinted from an article by Robert Goldfaden and Gary Goldfaden, MD in LIFE EXTENSION MAGAZINE
RevivLash™ Lash & Brow Stimulating Serum contains myristoyl pentapeptide-17, and glycoproteins like Grape Seed Proanthocyanidins, in addition to Keratinocyte Growth Factor and remarkable Redensyl®, to boost the appearance of thicker, longer, healthier eyelashes and eyebrows.