SerumScoop: Tips, tricks and news

Can Skincare Improve Your Overall Health?

Woman face hydration orchid serum

According to researchers
 at the University of California, San Francisco (UCSF), and the San Francisco Veterans Administ­ration Health Care System (SFVA), moisturized skin might prevent age-related ailments including Alzheimer's, heart disease and diabetes.

The cosmetic and personal care industry hears it all the time: the skin is the body’s largest organ; and we focus on its holistic status to treat signs of aging, or address compromised conditions. But what we do not often consider is how its negative health could affect our overall health—being the largest organ. A new pilot study from dermatol­ogists at UCSF and the SFVA brings this perspective to light.

Inflammation, Aging and the Skin

According to the researches, as humans age, low levels of inflammation—or inflammaging—occur, driven by an increase in molecules in the blood known as cytokines. Such age-related inflammation has been linked to chronic diseases including Alzheimer’s, cardiova­scular disease and diabetes. And while scientists suspected the inflammation stemmed from the immune system or liver, this group of dermatol­ogists have a different theory.

“The inflammation must come from an organ big enough that very minor inflammation can affect the whole body," explained study senior author Mao-Qiang Man, M.D, a research scientist in the UCSF, based at the SFVA Health Care System, who is also a visiting professor at Southern Medical University in Guangzhou, China. "Skin is a good candidate for this because of its size.”

While ordinarily, cytokines help to repair defects in the barrier; but in aging skin, the barrier is not so easily repaired, and inflammatory signals continue to be released, eventually reaching the blood.

Man added that with aging, dermatol­ogical symptoms such as itchiness, dryness and changes in acidity arise. So while skin may have minor inflammation, due to its relative size to the body, this elevates circulating cytokine levels. Furthermore, skin starts to deteriorate at around the age of 50, with changes to epidermal pH, hydration and the permeability barrier; and a loss in moisture or breaks in the permeability barrier also can cause the skin to release inflammatory cytokines.

While ordinarily, cytokines help to repair defects in the barrier, in aging skin, the barrier is not so easily repaired, so the inflammatory signals continue to be released, eventually reaching the blood.

“Until recently, the scientific community didn’t believe that skin could contribute to systemic inflammation and disease," said study lead author Theodora Mauro, M.D, a professor of dermatology at UCSF and the SFVA Health Care System. "But in the last five years, studies of psoriasis and dermatitis have shown that skin inflammation from these diseases likely increases the risk of heart disease."

Topical Treatment

Based on these and other observations, the researchers published a study in the Journal of the European Academy of Dermatology and Venereology, whereby they attempted to reverse age-related skin damage using an over-the-counter skin cream formulated with cholesterol, free fatty acids and ceramides, which had previously been shown to contribute to skin repair.

Using the cream reportedly lowered participants’ cytokine levels to be nearly equivalent with people in their 30s.

Thirty-three older adults between the ages of 58 and 95 years applied the cream all over their bodies twice daily for 30 days. After one month, the researchers measured blood levels of three cytokines—interleukin-1 beta, interleukin-6, and tumor necrosis factor (TNF) alpha—all of which have been implicated in age-related inflammatory diseases.

Use of the cream reduced the amount of all three cytokines, compared with both the participants’ levels before application of the cream and the levels of similarly aged adults who did not use the cream. In fact, using the cream reportedly lowered participants’ cytokine levels to be nearly equivalent with people in their 30s.

“We're going to see whether using the cream to keep epidermal function normal as people age will prevent the development of those downstream diseases,” said co-author Peter Elias, M.D., a UCSF professor of dermatology based at the SFVA Health Care System. “If we do, the implication would be that after the age of 50, you would want to be applying an effective topical barrier repair preparation daily for the rest of your life.”

— Reprinted/excerpted from Cosmetics & Toiletries® Magazine

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News Release: Reviv Serums Debuts HA7X Multi-Molecular Hydrator Serum

FIRST US SKINCARE PRODUCT WITH AWARD-WINNING NEUROPHROLINE ACTIVE COSMETIC INGREDIENT

SAN FRANCISCO CA USA, OCT 13, 2016 (PRNewswire): RevivSerums.com, a San Francisco-based global leader in cosmetic chemistry innovation, introduces a first-of-its-kind cosmetic topical, HA7X Multi-Molecular Hydrator Serum.

HA7X is one of the first products of its kind to include award-winning Neurophroline™ active cosmetic ingredient from the Active Beauty business unit of Givaudan, a group of companies headquartered in Switzerland. Neurophroline cosmetic ingredient won in-cosmetics 2016 Gold Award for Best Ingredient at its annual global showcase for personal care ingredients in Paris this spring.

A multi-dimensional approach to the application of topical hyaluronic and rejuvenating complexes, this first-of-its-kind dermo-biotech serum combines seven forms of hyaluronic technologies with the Neurophroline ingredient to deliver visible hydration, protection, plumping, smoothing, rejuvenation, and recovery from the skin's surface down to subcutaneous levels.

HA7X supports the skin’s natural ability to replenish its own scaffolding, tightening and cushioning, and targets the protection of skin from stressors like cortisol, pollution and UV.

“HA7X is another great example of innovative cosmetic chemistry from Reviv Serums,” said Maya Waldman, Director of Happiness for Reviv Serums. "There is clear demand for a product that addresses the target concerns: hydration, scaffolding, and the negative effects of stress and pollution, at a fair price. Our customers will love that this new serum also contains both instant-plumping, as well as timed-release components.”

HA7X includes 29 of the primary ingredients in the industry leading HA5 Rejuvenating Hydrator® by SkinMedica® / Allergan®. HA7X then includes two additional, new hyaluronic technologies (for a total of seven). Yet with these new actives, HA7X is about half the price as the SkinMedica product.

The Neurophroline ingredient is found in an exclusive and sustainable phyto extract, and is a unique bioactive cosmetic ingredient able to block the production of cortisol, the major stress hormone, by skin cells. It has also shown to promote the release of endorphins, a natural calming neuropeptide acting on mood and promoting a sense of well-being and relaxation.

The Neurophroline ingredient shows fast benefits in only 2 weeks, with a visible reduction of redness (up to 2.4x), a very fast recovery of skin luminosity (+57%), and improvement in global skin color (+99%) after only 28 days.

Environmental pollutants including cigarette smoke, ozone, exhaust fumes and heavy metals generate free radicals that induce oxidative damage and put skin cells in a state of stress. Givaudan’s active ingredient Neurophroline targets these sources and effects, which contributes to reducing the appearance of premature aging caused by environmental pollution.

"As we continue to build our premier global brand in award-winning personal care ingredients, we are excited about launching Neurophroline on the US market, winning the innovation award, and contributing to all of our customers’ success. We highly value Reviv’s commitment to formulating innovation into their products,” noted Romain Lemeunier, head of Givaudan Active Beauty North America. “The future looks very bright for skincare science, and skincare consumers.”

HA7X also contains several novel deepsea bioactives which target skin renewal and reactivity, and microspheres that impart an elegant silky texture and optical blurring effect.

https://youtu.be/Af3JxS7sPGU

HA7X Serum debuts at an introductory price of $89 for a limited time here. It is available immediately at RevivSerums.com, which ships to many countries worldwide with free shipping, and at select retailers, e-tailers, salons, medspas and physician's offices.

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RevivSerums.com is a wholly owned component of Astonishing Developments Ltd. based in San Francisco, a global leader in topical therapies for hair, scalp, lashes, face, neck and body.


Legal

HA7X is a trademark of Astonishing Developments Ltd. Other company and/or product names may be trade names, trademarks and/or registered trademarks of the respective owners with which they are associated. Astonishing Developments Ltd. and its RevivSerums.com products, including its HA7X Multi-Molecular Hydrator Serum product, are neither affiliated with, nor approved by, Allergan Inc., nor SkinMedica®. These statements have not been evaluated by the U.S. Food and Drug Administration. Products not intended to diagnose, treat, cure, or prevent any disease.

https://revivserums.com/products/ha7x-multi-molecular-hydrator-serum


hashtags:
#HA7X #skincare #Neurophroline #skinhydration #skinstressors #incosmetics

http://www.ireachcontent.com/news-releases/reviv-serums-debuts-ha7x-multi-molecular-hydrator-serum-596951691.html

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Rub it in!

Are skincare topicals more effective when rubbed in?

There are new scientific studies that show it's probably best to rub or apply pressure when applying skin topicals: it can actually increase penetration.

Depending on the specific rubbing experiment, there was a two- to three-fold increase in product retained in full-thickness skin with rubbing than without.

"While these findings cannot be generalized to all skin care and cosmetic ingredients, they provide a basis and preliminary evidence suggesting that massage can be an important factor when treating skin. Its influence may be compounded by specific physiochemical properties of the chemical as well as the duration, pressure, and quantity of application. In the meantime, rubbing is just one of many variables influencing efficacy that await in-depth evaluation."

See more here:
http://www.cosmeticsandtoiletries.com/research/universitydata/Skin-Care-Gets-a-Good-Rub-Down-The-Role-Massage-Plays-in-Cosmetic-and-Skin-Care-382510341.html

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Chronobiology: Does skin have a circadian rhythm?

Best time of day to apply Reviv Serums

The skin goes through different phases in 24 hours. During the day, it defends itself against external aggressions like the wind, the sun, the cold, or pollution. At night, it regenerates.


It was evidenced that the highest number of cell divisions occurs between midnight and 1am, and the lowest between 12pm and 1pm. The skin's blood flow is at its maximum between 11pm and 4am, which makes it possible to provide nutrients and remove toxins. And it is between 7pm and 11pm that desquamation on the superficial stratum corneum is the most important.

In addition, the skin has receptors for melatonin which, on top of their role as circadian synchronizers, are excellent at trapping free radicals. In the late 1990s, researchers highlighted the existence of the "Clock" gene as a central regulator for monitoring the circadian clock.

According to Neil Astles, Marketing Manager for biofunctional actives at Ashland Specialty Ingredients, "more than 20% of the expression of a tissue's genes depends on circadian regulation".

"In Asia, it is said that the first three hours of sleep, called 'Golden Time', are the most important for the skin. In Korea, there is also an expression, meaning 'well-slept face', to refer to a beautiful face. It is conveyed by the face of a sleeping woman", explains Florence Bernardin, expert in Asian cosmetics trends and founder of the Information & Inspiration marketing intelligence firm.

Excerpts from...
http://www.sciencedaily.com/releases/2013/07/130723155002.htm

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