SerumScoop: Tips, tricks and news
RevivHair Max gets an upgrade:
RevivHair Max Hair Stimulating Serum now encapsulates its existing primary hair actives Redensyl, Capixyl, and Procapil, in a phospholipid microsphere, which "containerizes" it.
Such microsphere containers form a transfer system that enhances penetration, as they transfer the actives to the capillary bulbs.
With such a liposome we can enhance the delivery of actives to maximize their ability to effectively penetrate, boosting their efficacy, strength and bioavailability.
Since such a container also has a timed-release benefit, since it releases its actives over time compared to non-encapsulated actives.
How are our liposomes designed?
These microscopic vesicles consist of an aqueous center with a phospholipid membrane. Phospholipids contain a glycerol bonded to two fatty acids and a phosphate group with a polar head. The fatty acid portion of this biomolecule is hydrophobic and is located toward the outside of the lipid bilayer, and the phosphate group is hydrophilic and faces the aqueous interior.
These phospholipid walls are identical to those that comprise human cell membranes, and are readily compatible with epidermal surface lipids, the skin’s primary moisture barrier.
When a liposome fuses with epidermal lipids, the epidermal lipid structure becomes overloaded with water and out of equilibrium. To restore equilibrium, the water and phospholipid, as well as the loaded actives, are rapidly churned through the top cell layers of the stratum corneum. Enhanced delivery of the active occurs as it is rapidly carried down through the stratum corneum.
Liposomes’ proven delivery system yields a multitude of benefits; enhancing the penetration of actives yielding increased efficacy, offering time release mechanisms, and protecting and delivering otherwise unstable ingredients.
Liposomes are also known to improve the skin barrier function and decrease transepidermal water loss (TEWL) shortly after application. In addition, phospholipids contain a high content of phosphatidylcholine which has excellent moisturizing properties.
We have decided to keep RevivHair Max at the same cost for now, despite its considerable COGS (Cost of Goods Sold). Its price has not changed over multiple upgrades. We know times can be tough, and we want to keep Max affordable for our diverse customer base.
For the most part, you won't notice a difference compared to the prior RevivHair Max formulation. It's simply slightly more cloudy (but not particularly perceptible), and slightly thicker.
New and improved RevivHair Max with Liposomal RCP is already shipping! Get it today here.
We use novel PhytoCellTec Malus stem cells in our RevivHair Max Hair Stimulating Serum to target the process of postponing follicle aging. Here's an article from SOFW Journal that describes a scientific study which shows this ingredient "was found to slightly but clearly postpone senescence- and apoptosis-induced necrosis."
PhytoCellTec™ Malus Domestica Study results
Age-Delaying Effect on Human Hair Follicles
Human hair follicles can be isolated by microdissection from skin fragments that are left after facelift surgery. Only follicles in the anagen phase are collected. Hair follicles are mini organs that represent a natural coculture model of epidermal and melanocyte stem cells and differentiated cells. The follicles can be maintained in a growth medium where they elongate until about day 14. Then the follicle cells gradually become senescent or undergo apoptosis which is a programmed cell death. Because of the lack of blood circulation, isolated hair follicles cannot be kept alive and growing for a longer period. But isolated hair follicles are test models to screen for actives that can delay the necrosis process. Addition of 0.2% of an extract of Uttwiler Spätlauber stem cells was found to slightly but clearly postpone senescence- and apoptosis-induced necrosis. Fig. 6 shows that follicles kept in presence of the Uttwiler Spätlauber stem cell extract continued to elongate until day 18, whereas the control follicles started to shrink after day 14.
- Increases the colony forming efficiency of epidermal stem cells
- Maintenance of dermal stem cell characteristics
- Maintenance of regenerative potential of keratinocytes in hair follicles
- Age-delaying effect on isolated hair follicles
- Increases lifespan/growth phase of isolated hair follicle
- Reduction of hair loss
- Increase in hair density
Read more about PhytoCellTec Malus Domestica Hair here.