Scientists Find Mitochondrial Complex II Declines with Age

A new study has found the activity of mitochondrial complex II, which is a key metabolic enzyme found in human skin cells, declines as humans age.

These findings, as published in the Journal of Investigative Dermatology, help scientists at Newcastle University, UK, better understand human skin cells. With this knowledge, the researchers can create potential anti-aging treatments and cosmetic products specialized to work against the decline in the enzyme’s activity levels.

With these results, scientists can develop more treatments for age-related diseases, such as cancer, with the understanding of how other body organs age.

Reflections from the Study’s Leading Professor

The leaders of the study were Mark Birch-Machin, professor of molecular dermatology at Newcastle University and Amy Bowman, Ph.D., research associate at Newcastle University's Institute of Cellular Medicine, along with part of Birch-Machin’s research group. Birch-Machin shared his insights about the research.

"As our bodies age we see that the batteries in our cells run down, known as decreased bio-energy and harmful free radicals increase. This process is easily seen in our skin as increased fine lines, wrinkles and sagging appears.

"Our research means that we now have a specific biomarker, or a target, for developing and screening anti-aging treatments and cosmetic creams that may counter this decline in bio-energy.

"There is now a possibility of finding anti-aging treatments, which can be tailored to differently aged and differently pigmented skin, and with the additional possibility to address the aging process elsewhere in our bodies."

The Research
To determine if there was a difference in activity as age increases, the complex II activity was measured in 27 donors, aged 6 through 72.

Samples were taken from a sun-protected area of skin, and techniques were used to measure the activities of the key enzymes within mitochondria. The mitochondria are involved in producing the skin cell’s energy derived from the epidermis and dermis, or higher and lower levels of skin.

The complex II activity showed cells derived from the lower levels declined with age, per unit of mitochondria. The amount of enzyme protein decreased due to the decline, and the decrease was only examined in the cells that stopped reproducing.

Continuing Studies
Future studies will now have to complete the requirement in setting up techniques to monitor anti-aging approaches in human skin, while also completely understanding skin’s functional consequences and other tissues.

"Newcastle University is pioneering research into aging as it has long been thought that mitochondria play an important role in the aging process, however the exact role has remained unclear,” said Bowman. “Our work brings us one step closer to understanding how these vital cell structures may be contributing to human aging, with the hope of eventually specifically targeting areas of the mitochondria in an attempt to counteract the signs of aging."

A recent study on mice showed the activity of complex II is lower in the skin of naturally aged older mice, in comparison to the skin of younger mice.

- See more at: http://www.cosmeticsandtoiletries.com/research/biology/Scientists-Find-Mitochondrial-Complex-II-Declines-with-Age-373083051.html

Many of the primary ingredients in our serums target the support of mitochondria. Of special note is the NANO-LIPOBELLE™ DN CoQ10 ingredient in our TelomErase 6-in-1 Multi-Corrective Serum. Here's a study on the positive, supportive effects of this product on mitochondria: http://bit.ly/1LHc70j

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Review Showcase of TelomErase Serum

Terrific reviews of new TelomErase 6-in-1 Multi-Corrective Serum continue to flow in as word spreads. Beauty bloggers LOVE the new product. Here's a compendium of the latest review site posts:

 

 

http://liz-breygel.blogspot.com.br/2015/11/telomerase-serum-by-reviv-serums-review.html https://samplesandfreebiesgallery.wordpress.com/2015/11/11/revivserums-telomerase-serum-triple-telomere-targeting-6-in-1-multi-corrective-review
http://www.venuslovesvirgo.com/2015/11/telomerase-triple-telomere-targeting.html http://www.angiewagg.com/2015/11/telomerase-serum-triple-telomere.html https://lifestylebites3.wordpress.com/2015/11/11/review-reviv-serums-telomerase-serum http://glamamamasgoodies.blogspot.com/2015/11/telomerase-serum-triple-telomere.html http://www.hannamarielei.com/2015/11/telomerase-serum-review-triple-telomere.html http://feastyoureyesonthis.weebly.com/katelyns-blog/telomerase-serum-review#comments
http://sunshinegirlblog.com/2015/11/its-time-to-erase-the-signs-of-aging-recharge-the-skin
http://tricias-list.com/telomerase
http://simple-savings-with-lex.blogspot.com/2015/11/telomerase-serum-triple-telomere.html
http://thirty-somethingblog.blogspot.com/2015/11/telomerase-serum-review-triple-telomere.html
http://www.luminousmom.com/reviv-serums-telom-erase-serum-love
http://bxquisite.net/2015/11/09/telomerase-serum-i-revivserums-com-review
http://julietlylillyrose.com/2015/11/09/5-ways-to-mix-foundation
http://foolsuk.com/telomerase-serum-triplt-telomere-targeting-6-in-1-multi-corrective
https://katierosereviews.wordpress.com/2015/11/10/review-remarkable-new-telomerase-serum-triple-telomere-targeting-6-in-1-multi-corrector
http://thatssomimi.blogspot.com/2015/11/so-mimi-reviews-telomerase-triple.html
http://www.abqinspired.com/a-little-serum-goes-a-long-way-november-8

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Debuting Another Cosmetic Chemistry Landmark: TelomErase Serum

The first product of its kind delivering unparalleled skin rejuvenation benefits


SEPT 30, 2015/PRNEWSWIRE - RevivSerums.com, a San Francisco-based global leader in cosmetic chemistry innovation, introduces a first-of-its-kind skincare cosmetic topical, TelomErase Triple Telomere Targeting Serum.

A conference by Nobel laureate Dr. Elizabeth Blackburn at the recent American Academy of Dermatology conclave in San Francisco underlined the clear correlation between the length and integrity of telomeres (DNA strand endcaps) with overall health & skin condition. TelomErase Serum combines three novel components known to target the support of those structures: Cycloastragenol, Telosomyl and Renovage.

A unique 6-in-1 multi-corrective formula, TelomErase also blends instant, short and long-term acting ingredients into a single powerful serum that can visibly reduce the appearance of sags & bags, dark circles, fine lines, sunspots, redness, pore size & laxity without irritation, downtime or acclimation concerns.

"Over a year in development, TelomErase Serum is the very latest in cosmetic chemistry," said Vance Nesbitt, Director of 'Lotions and Potions' for RevivSerums. "It's the greatest combination of hard-to-source ingredients blending instant-working bioactives along with long-term anti-aging components. Our customers have been asking for such a multi-corrective, at a reasonable price, and we think they'll be elated with the results."

TelomErase incorporates a number of novel cosmetic ingredients sourced worldwide, including:

PEPHA®-TIGHT delivers a fast, instant tightening experience; Eyeseryl® & REGU®-AGE have recognized efficacy against puffy eyebags & dark circles.

SymSitive® 1609 works as a fast-acting “anti-nerve hyper-activator” to calm over-reaction of hypersensitive skin & help prevent stinging & tingling.

aFGF (Recombinant Human acidic Fibroblast Growth Factor) can help remove the appearance of pigmentation, improve complexion, reverse skin damage and tighten skin.

Nano-Lipobelle® DN CoQ10 is a supersaturated double phospholipid nano-emulsion liposome that contains ultra-small particles of highly purified coenzyme Q10, tocopherol (vitamin E) and THD Ascorbate (a novel, potent and expensive form of Vitamin C). Together, they ensure fast penetration into deeper skin layers to maintain activity & potency and become a potent moisturizer, antioxidant & whitening agent.

The serum's base is a sea kelp bioferment with superb skin feel and slip. It can be compared to the famed "miracle broth" found in La Mer® products. Unscented, it is preserved with a safe, worldwide Eco-certified ingredient.

View a short video about the new serum here.

TelomErase Serum debuts at an introductory sale price of $149 (2 oz.) for a limited time here. It is available immediately at RevivSerums.com, and can be shipped to many countries worldwide with flat-fee shipping.

###

Contact: Bill Henderson pressrelations@revivserums.com

RevivSerums.com is a wholly owned component of Astonishing Developments Ltd. based in San Francisco, a global leader in topical therapies for hair, scalp, lashes and skin.

Legal
TelomErase Serum is a trademark of Astonishing Developments Ltd. Other company and/or product names may be trade names, trademarks and/or registered trademarks of the respective owners with which they are associated. These statements have not been evaluated by the U.S. Food and Drug Administration. Products not intended to diagnose, treat, cure, or prevent any disease.

 http://finance.yahoo.com/news/revivserums-com-launches-telomerase-triple-152000133.html

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Caffeine and hair loss

It has been shown recently that caffeine can help prevent hereditary and hormonal hair loss in men and women.

We use a liposomal caffeine in our RevivScalp. "Liposomal" in that the caffeine is encapsulated in a phospholipid to containerize it. With a liposome we can enhance the delivery of caffeine to maximize its ability to effectively penetrate the stratum corneum, boosting its efficacy, strength and bioavailability.

Here are some published scientific articles:

Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/ins-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro.
http://www.ncbi.nlm.nih.gov/pubmed/24836650

Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro.
http://www.ncbi.nlm.nih.gov/pubmed/17214716


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