SerumScoop: Tips, tricks and news
A primary active in our RevivHair Stimulating Serum and RevivLash Lash & Brow Stimulating Serum: Keratinocyte Growth Factor (KGF or rh-Polypeptide-3). Numerous scientific/clinical studies show how KGF helps promote hair growth. Check out these published articles:
Danilenko, Dimitry M.; Ring, Brian D.; Yanagihara, Donna; Benson, William; Wiemann, Bernadette; Starnes, Charles O.; Pierce, Glenn F. (1995). Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. American Journal of Pathology 147: 145-54.
Richardson GD; Bazzi H; Fantauzzo KA; Waters JM; Crawford H; Hynd P; Christiano AM; Jahoda CA. (2009). KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.
Karvinen, S; Pasonen-Seppanen, S; Hyttinen, JM; Pienimaki, JP; Torronen, K; Jokela, TA; Tammi, MI; Tammi, R (2003) Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan syntheses 2 and 3. J Biol Chem, 278:49495-49504
Braun S; Krampert M; Bodó E; Kümin A; Born-Berclaz C; Paus R; Werner S. (2006) Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents Journal Cell Science, 119: 4841-4849
Jang, JH (2005) Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2). Biotechnology Letters, 27:749-52.
Aging can take a heavy toll on the eyelashes, making them noticeably thinner, shorter, and more brittle. Many people resort to commercial products to create an illusion of improvement, but they fail to address the underlying causes.
Current treatments include drugs originally developed to treat glaucoma.1 The hefty price tag and side effects associated with these drugs prompted scientists to search for safer alternatives.2,3
In this article, you’ll learn how scientists uncovered natural compounds that work in complementary ways to protect and strengthen the structural foundation of eyelashes—naturally making them healthier, longer, and thicker.
Getting to the Root of Eyelash Growth
Stem cells are responsible for the constant self-renewal and repair of the skin. They have the unique ability to either remain a stem cell or transform into a specialized cell type through cell division.4 Research shows that stem cells reside at the base of each hair follicle where they facilitate hair regeneration.5 These are referred to as hair follicle stem cells.
Each eyelash follicle rotates through the same three stages of growth as other body hair follicles. The first stage (anagen) is the growth phase that lasts roughly one to two months.6 It is characterized by stem cells giving rise to specialized cells called keratinocytes with two main functions: 1) producing the hair shaft visible above the skin, and 2) synthesizing the tough and fibrous protein keratin that adds fullness, length, and strength to the hair shaft.7-9
As the eyelash follicle enters the second or transitional stage (catagen), which lasts approximately two weeks, it begins to shrink and hair growth ceases. In the third and final stage (telogen), the eyelash follicle becomes active once again, producing new hair that emerges from the skin’s surface by pushing out old hair to shed naturally. Telogen is the longest phase for eyelashes, lasting around four to nine months.6
As a person ages, exposure to ultraviolet (UV) radiation compromises the regenerative capacity of hair follicle stem cells.10 Keratin production also diminishes in hair follicles.11 Together, these age-associated changes lead to the outward appearance of weak, thin, and short eyelashes.
Fortunately, scientists have uncovered compounds that effectively target these changes to improve the appearance of eyelashes.
Novel Plant Extract Safeguards against Ultraviolet Radiation
Ultraviolet radiation induces oxidative stress in hair follicle stem cells that reduces their vitality and activity, in turn diminishing the health and longevity of the eyelashes.12,13 Scientists began investigating safe and effective compounds that protect hair follicle stem cells against the consequences of sun exposure. Plant stem cells derived from a rare grape variety quickly stood out.
Gamay Teinturier Fréaux grapes grow in an east-central region of France. They have red flesh and juice that signifies a high content of anthocyanins, flavonoids that combat oxidative stress through potent free radical scavenging activity.14,15 The unique synergy between anthocyanins and other metabolites present in the grape provides frontline defense against ultraviolet damage.16
The capacity of stem cells to form colonies, known as colony-forming efficiency, is a key measure of their vitality and activity. Ultraviolet radiation has been shown to decrease colony-forming efficiency. Researchers conducted a laboratory experiment in which skin stem cells were treated with or without grape stem cell extract before exposure to ultraviolet radiation. While untreated cells experienced a 58% decrease in colony-forming efficiency, no changes were seen in treated cells. This demonstrated that treated cells were safeguarded against harmful ultraviolet radiation.16
Let’s now take a look at how a recently developed peptide significantly enhances eyelash growth.
Myristoyl Pentapeptide-17 Stimulates Eyelash Growth
The formation of keratin in the anagen phase is essential for eyelash growth and density. With advancing age, this process fails to run smoothly.11 To combat age-related decline in keratin synthesis, scientists developed a peptide called myristoyl pentapeptide-17. It has been shown in laboratory experiments to increase the expression of keratin genes by up to 160%, thereby boosting keratin production.17 This has translated into striking results in human clinical studies.
In a recent trial, 15 human volunteers ranging in age from 24 to 82 applied an eyeliner serum containing myristoyl pentapeptide-17 to the roots of their lashes. The researchers used computer-assisted image analysis software to assess eyelash characteristics. They observed a 25% increase in eyelash length and thickness in just 14 days!17
Even more impressive, another study revealed that participants applying an eyeliner serum with myristoyl pentapeptide-17 to the target area increased eyelash thickness and length by 72% after six weeks. Both studies reported no adverse side effects.17
Glycoproteins Support Hair Follicle Formation
Glycoproteins are large molecules composed of carbohydrate and protein. They form a vital part of the extracellular matrix that provides a proper environment for the development of new hair follicles. In fact, research indicates that glycoproteins act as powerful chemical messengers between the layers of the skin to jumpstart eyelash growth.18,19
Panthenol Exerts Powerful Moisturizing Effects
Panthenol has been a mainstay ingredient in hair products for the past two decades and for good reason. It is a derivative of pantothenic acid (vitamin B5), a vital component of coenzyme A that assists in metabolic functions such as protein and lipid synthesis. Panthenol is converted into pantothenic acid in the hair shaft where it effectively binds water molecules, thereby improving eyelash moisture.20
Current treatments to improve aging eyelashes come with a steep price and substantial side effects, making them an unattractive option for many people. Fortunately, scientists have identified a network of complementary compounds, including a novel plant extract, myristoyl pentapeptide-17, glycoproteins, and panthenol, which protect and strengthen hair follicles to naturally deliver healthier, longer, and thicker eyelashes.
— Excerpted/reprinted from an article by Robert Goldfaden and Gary Goldfaden, MD in LIFE EXTENSION MAGAZINE
RevivLash™ Lash & Brow Stimulating Serum contains myristoyl pentapeptide-17, and glycoproteins like Grape Seed Proanthocyanidins, in addition to Keratinocyte Growth Factor and remarkable Redensyl®, to boost the appearance of thicker, longer, healthier eyelashes and eyebrows.
If you’re balding, it’s a lot harder to grow all your hair back than it is to stop your follicles from disappearing in the first place. Slow the erosion of your hairline with these five dermatologist-approved strategies.
1. Meditation and Exercise
In balding men, periods of rapid shedding are often brought on by stress. The reason? Stress floods your body with the hormone cortisol, and then other hormone levels fluctuate in response, says Melissa Piliang, M.D., a hair-loss expert at Cleveland Clinic.
If you’re predisposed to balding, this can speed the process. To better control your stress, you might want to try traditional meditation or, if that’s not your thing, an active meditation regimen such as yoga or tai chi.
Or just commit to getting in better shape.
A 2015 study in PLOS One found that older men with a high level of cardio respiratory fitness release 42 percent less cortisol throughout the day than unfit men do. The stress hormone has been linked to all sorts of diseases.
Minoxidil (Rogaine) probably won’t restore what’s lost, but it can help you hold on to what’s left and even help you regrow a bit. The topical med increases bloodflow as well as oxygen and nutrient delivery to the follicle.
Liquid Rogaine can cause irritation and leave a greasy coating on your hair, so opt for the 5 percent foam, says Dr. Piliang.
Rogaine costs only $29.99 a month (rogaine.com), but you’ll have to use it forever to retain any gains. [Note that solubilizers required to dissolve minoxidil are known irritants.]
Rub it into your scalp in the morning and again at night for the most benefit. Bonus: Unlike the oral medication finasteride (the other FDA-approved drug, sold as Propecia), minoxidil isn’t linked with erectile dysfunction or decreased libido.
3. Laser Devices
Besides minoxidil and finasteride, laser devices are the only other hair-loss treatment cleared by the FDA in recent years. The devices are sold as wands or Star Wars-worthy helmets for $200 to nearly $900.
In the largest study, published in 2014 in the American Journal of Clinical Dermatology, men who zapped their scalp three times a week saw a significant increase in hair density after 26 weeks.
One theory is that lasers have an antioxidant effect on hair follicles. But before you rush out to buy a six-pack of combs, understand that “hair growth” doesn’t necessarily mean “hair other people can see.”
You will likely feel it, though, which may have a placebo effect on your confidence.
4. Ketoconazole Shampoo
Swap your standard shampoo for a brand with 1 percent ketoconazole, such as Nizoral ($13 for 7 ounces, drugstore.com). Or ask your doctor to prescribe the 2 percent version.
“It’s marketed as an antidandruff ingredient, but there’s solid research ketoconazole is an anti-androgen,” says Dr. Piliang.
Anti-androgens block the conversion of testosterone to D•HT, the signaling molecule that shrinks hair follicles.
That’s how finasteride works too, but because ketoconazole is confined to the scalp, it doesn’t have the risk of negative sexual side effects, she says.
Massage the shampoo into your scalp, step out of the shower stream, wait 2 to 3 minutes, and rinse.
5. Vitamin D
A British Journal of Dermatology study reported that people with alopecia areata, an autoimmune disorder that causes hair loss, were three times as likely to be D deficient as those with healthy hair. “Vitamin D helps hair reset its growth phase,” explains Dr. Piliang.
To jumpstart your follicles, she recommends taking 2,000 IU a day of vitamin D3, especially in winter when you’re exposed to less sunlight.
But don’t try baking your bald spot in the sun to ramp up your vitamin D production. That might result in an even bigger problem.
“Men should be careful about sun exposure on a balding scalp, since it’s a common location for skin cancers,” Dr. Piliang warns.
— Reprinted / excerpted from Men's Health Magazine
We would of course add a recommendation: the remarkable RevivHair™ line of stimulating products. Proven RevivHair Max Stimulating Serum, transforming RevivScalp Rejuvenating Scalp Serum Masque, and RevivHair Stimulating Shampoo & Conditioner. Boost your results 2 to 4 times a year with RevivHair Placode Booster Serum. The RevivHair line provides a full compliment of the latest in cosmetic chemistry to help boost the appearance of thicker, denser, stronger, healthier hair.
Here's a compendium of renowned beauty blogger & beauty review site publications who evaluated remarkable RevivLash:
CRESSATINE is a primary component of our RevivScalp Rejuvenating Scalp Serum Masque. CRESSATINE is a novel aqueous extract of watercress (Nasturtium officinale) and Indian cress (Tropaeolum majus) leaves and shoots, stabilized with plant glycerin, and is ECOCERT qualified.
Excerpts from its specification documentation, prepared by its manufacturer, France-based Solabia:
Titrated with sulfur, CRESSATINE is designed to facilitate hair growth and strengthen hairs from the root:
- by providing the elements (sulfur and other minerals) needed to produce keratin for solid, well-structured hair.
- by helping initiate hair regrowth via the Wnt pathway.
- by stimulating keratinocyte differentiation via the KGFs (keratinocyte growth factors) released when the Wnt/β-catenin pathway is activated.
- by prolonging the growth phase using the Wnt pathway and KGFs.
ACTIVATION OF WNT/ ß-CATENIN SIGNALING PATHWAY
CRESSATINE was shown to boost the activation of WNT / ß-CATENIN signaling pathway by 37% vs. control:
STIMULATION OF KGF PRODUCTION
CRESSATINE® significantly stimulates KGF production, by 107% vs. control, and in a dose-dependent manner, which in turn stimulates the keratinocytes, causes a well- structured hair to be produced, and lengthens the anagen phase: