Can Skincare Improve Your Overall Health?

Woman face hydration orchid serum

According to researchers
 at the University of California, San Francisco (UCSF), and the San Francisco Veterans Administ­ration Health Care System (SFVA), moisturized skin might prevent age-related ailments including Alzheimer's, heart disease and diabetes.

The cosmetic and personal care industry hears it all the time: the skin is the body’s largest organ; and we focus on its holistic status to treat signs of aging, or address compromised conditions. But what we do not often consider is how its negative health could affect our overall health—being the largest organ. A new pilot study from dermatol­ogists at UCSF and the SFVA brings this perspective to light.

Inflammation, Aging and the Skin

According to the researches, as humans age, low levels of inflammation—or inflammaging—occur, driven by an increase in molecules in the blood known as cytokines. Such age-related inflammation has been linked to chronic diseases including Alzheimer’s, cardiova­scular disease and diabetes. And while scientists suspected the inflammation stemmed from the immune system or liver, this group of dermatol­ogists have a different theory.

“The inflammation must come from an organ big enough that very minor inflammation can affect the whole body," explained study senior author Mao-Qiang Man, M.D, a research scientist in the UCSF, based at the SFVA Health Care System, who is also a visiting professor at Southern Medical University in Guangzhou, China. "Skin is a good candidate for this because of its size.”

While ordinarily, cytokines help to repair defects in the barrier; but in aging skin, the barrier is not so easily repaired, and inflammatory signals continue to be released, eventually reaching the blood.

Man added that with aging, dermatol­ogical symptoms such as itchiness, dryness and changes in acidity arise. So while skin may have minor inflammation, due to its relative size to the body, this elevates circulating cytokine levels. Furthermore, skin starts to deteriorate at around the age of 50, with changes to epidermal pH, hydration and the permeability barrier; and a loss in moisture or breaks in the permeability barrier also can cause the skin to release inflammatory cytokines.

While ordinarily, cytokines help to repair defects in the barrier, in aging skin, the barrier is not so easily repaired, so the inflammatory signals continue to be released, eventually reaching the blood.

“Until recently, the scientific community didn’t believe that skin could contribute to systemic inflammation and disease," said study lead author Theodora Mauro, M.D, a professor of dermatology at UCSF and the SFVA Health Care System. "But in the last five years, studies of psoriasis and dermatitis have shown that skin inflammation from these diseases likely increases the risk of heart disease."

Topical Treatment

Based on these and other observations, the researchers published a study in the Journal of the European Academy of Dermatology and Venereology, whereby they attempted to reverse age-related skin damage using an over-the-counter skin cream formulated with cholesterol, free fatty acids and ceramides, which had previously been shown to contribute to skin repair.

Using the cream reportedly lowered participants’ cytokine levels to be nearly equivalent with people in their 30s.

Thirty-three older adults between the ages of 58 and 95 years applied the cream all over their bodies twice daily for 30 days. After one month, the researchers measured blood levels of three cytokines—interleukin-1 beta, interleukin-6, and tumor necrosis factor (TNF) alpha—all of which have been implicated in age-related inflammatory diseases.

Use of the cream reduced the amount of all three cytokines, compared with both the participants’ levels before application of the cream and the levels of similarly aged adults who did not use the cream. In fact, using the cream reportedly lowered participants’ cytokine levels to be nearly equivalent with people in their 30s.

“We're going to see whether using the cream to keep epidermal function normal as people age will prevent the development of those downstream diseases,” said co-author Peter Elias, M.D., a UCSF professor of dermatology based at the SFVA Health Care System. “If we do, the implication would be that after the age of 50, you would want to be applying an effective topical barrier repair preparation daily for the rest of your life.”

— Reprinted/excerpted from Cosmetics & Toiletries® Magazine

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Beauty Influencer Evaluates Revivinol "Unretinol" Serum

Before and after photos of alt-Retinol product cheaper bigger better than Biossance Squalane + Phyto-Retinol Serum

Beauty Influencer @bawbby_ reviews new Revivinol Serum, the first dual powerhouse natural alternative to retinol — without the downsides!

“I just finished my 10th use of Revivinol Serum and I couldn’t wait to finally share my thoughts! My main area of concern was this horrible breakout of red bumps I’ve had on my forehead for TWO YEARS. Nothing I tried would fix it, so I covered it with makeup and airbrushing for photos. But after 10 days with this serum, the bumps are GONE and my skin tone has even improved! My entire face looks and feels the best it has in years. I am completely blown away, I thought nothing would ever work for my stubborn skin! I am being 100% honest when I tell you this serum has changed my life. I feel 110% more confident without those unsightly bumps and my red patches.

…this serum is truly amazing and I will continue faithfully using it and recommending it to EVERYONE. Nothing in my life has ever worked as well on my problematic skin as this serum!”

Get Revivinol Serum, a full 2 ounces in size, at a great price here at RevivSerums.com


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All About Sytenol A in remarkable Revivinol Serum

Before After photos Sytenol A Bakichiol in Revivinol Serum

Sytenol® A - A Functional Analog of Retinol From the perspective of topically applied compositions, a small molecule without having the negatives of Retinol that safely mimics the properties of Retinol (Fisher et al., FASEB J,1002-1013, 1996) is a greatly sought after ingredient.

Volcanic plots illustrate the molecular signatures of Retinol and Sytenol® A of a DNA microarray experiment using reconstructed full thickness epidermis. This shows a very similar overall shape, indicating similar overall modulation of gene expressions in the skin substitute model. Multiple comparative studies revealed Sytenol® A to be the true alternative to Retinol (Chaudhuri, In Cosmeceuticals and Active Cosmetics, 3r Edition, Eds., Maibach et al., Chapter 1, 1-18, 2015) for anti-aging applications and does not have the inherent safety & stability issues of Retinol.

A recent randomized, double-blind clinical study between Sytenol® A and Retinol carried out by UC-Davis Dermatologists demonstrated that both compounds significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The Retinol users reported more facial skin scaling, burning and stinging. Authors concluded that Sytenol® A is a more tolerable alternative to Retinol (Dhaliwal et al, British J Dermatology, 2018 Jun 27. doi: 10.1111/bjd.16918).

Clinically Proven to Reduce Multiple Signs of Aging

Protocol:
• Human volunteers – 17; 16 Completed; Age – 41 to 60 yrs; Caucasian (14), Hispanics (2)
• Study duration – 12 weeks
• Test sites – Full face
• Test substance – Lotion with 0.5% Sytenol® A; Contains No sunscreen and No moisturizer
• Application frequency – About 2 g twice a day
• Methodology – Expert grading/Self-assessment by panelists (Grading 0 to 4): (1) Roughness & Dryness; (2) Fine lines & wrinkles; (3) Skin tone; (4) Skin elasticity & firmness; (5) Radiance; (6) Brightening; (7) Overall eye-area appearance; Silicone Replica Analysis: Wrinkle depth & Skin roughness; Photography: Before & after the treatments; Readings were taken at baseline, 4, 8 & 12 weeks.

• Statistical Analysis – Statistical significance defined as p ≤0.05

Results

The results clearly showed that, after twelve weeks treatment, significant improvement in lines and wrinkles, pigmentation, elasticity, firmness and overall photo-damage was observed, with no irritating effect on skin. Based on these results and the comparative studies of Retinol and Sytenol® A done by Sytheon, we conclude that Sytenol® A is the first true Retinol-like anti-aging product (Chaudhuri & Bojanowski, Intern J Cosmet Sci, 36(3):221-230, 2014).


Get the remarkable benefits of Sytenol A in Revivinol "Unretinol" Serum here.

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The Difference Between Inflammation and an Allergic Reaction

SerumScoop blog on inflammation vs allergic reaction

How is inflammation different from an allergic reaction?…

Inflammation

Inflammation is the body’s normal reaction to threat. It is a process by which the immune system recruits its resources—e.g., cells, small peptides named cytokines, hormones and the like—to battle an invader such as bacteria, radiation or a chemical.

In order to eradicate the threat, the immune system initiates a cascade of reactions, collectively termed inflammation. These eventually lead to a resolution and healing.

To pave paths to the site of inflammation, the body elevates the site’s temperature, blood flow, nerve sensation, etc. This is manifested in the skin as redness (erythema), swelling (edema) and local heat.

Allergic reaction

An allergy is a specific immune reaction, typically to a chemical invader that is often a protein or a peptide. This reaction requires genetic predisposition; that is, only certain individuals who express specific proteins are allergic to specific type of chemical exposure.

Every allergy triggers inflammation, but not every inflammatory response is due to an allergy. Inflammation can also be triggered by an irritant, which does not require genetic predisposition and affects the entire population, or to harmful bacteria; in this case, it is referred to as an infection.

- Excerpted from Cosmetics & Toiletries: Science Applied. Read more here

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