SerumScoop: Tips, tricks and news
Sytenol® A - A Functional Analog of Retinol From the perspective of topically applied compositions, a small molecule without having the negatives of Retinol that safely mimics the properties of Retinol (Fisher et al., FASEB J,1002-1013, 1996) is a greatly sought after ingredient.
Volcanic plots illustrate the molecular signatures of Retinol and Sytenol® A of a DNA microarray experiment using reconstructed full thickness epidermis. This shows a very similar overall shape, indicating similar overall modulation of gene expressions in the skin substitute model. Multiple comparative studies revealed Sytenol® A to be the true alternative to Retinol (Chaudhuri, In Cosmeceuticals and Active Cosmetics, 3r Edition, Eds., Maibach et al., Chapter 1, 1-18, 2015) for anti-aging applications and does not have the inherent safety & stability issues of Retinol.
A recent randomized, double-blind clinical study between Sytenol® A and Retinol carried out by UC-Davis Dermatologists demonstrated that both compounds significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The Retinol users reported more facial skin scaling, burning and stinging. Authors concluded that Sytenol® A is a more tolerable alternative to Retinol (Dhaliwal et al, British J Dermatology, 2018 Jun 27. doi: 10.1111/bjd.16918).
Clinically Proven to Reduce Multiple Signs of Aging
• Human volunteers – 17; 16 Completed; Age – 41 to 60 yrs; Caucasian (14), Hispanics (2)
• Study duration – 12 weeks
• Test sites – Full face
• Test substance – Lotion with 0.5% Sytenol® A; Contains No sunscreen and No moisturizer
• Application frequency – About 2 g twice a day
• Methodology – Expert grading/Self-assessment by panelists (Grading 0 to 4): (1) Roughness & Dryness; (2) Fine lines & wrinkles; (3) Skin tone; (4) Skin elasticity & firmness; (5) Radiance; (6) Brightening; (7) Overall eye-area appearance; Silicone Replica Analysis: Wrinkle depth & Skin roughness; Photography: Before & after the treatments; Readings were taken at baseline, 4, 8 & 12 weeks.
• Statistical Analysis – Statistical significance defined as p ≤0.05
The results clearly showed that, after twelve weeks treatment, significant improvement in lines and wrinkles, pigmentation, elasticity, firmness and overall photo-damage was observed, with no irritating effect on skin. Based on these results and the comparative studies of Retinol and Sytenol® A done by Sytheon, we conclude that Sytenol® A is the first true Retinol-like anti-aging product (Chaudhuri & Bojanowski, Intern J Cosmet Sci, 36(3):221-230, 2014).
Get the remarkable benefits of Sytenol A in Revivinol "Unretinol" Serum here.
RevivSerums.com Debuts Novel "Unretinol" Serum: Revivinol
First skincare product worldwide with new blend of natural alternatives to retinol
San Francisco, CA (PRUnderground) January 22nd, 2019
RevivSerums.com, a San Francisco-based global leader in cosmetic chemistry innovation, introduces a first-of-its-kind topical product, Revivinol “Unretinol” Serum.
This potent breakthrough serum features Revivinol, a combination of two patented compounds making it the first natural true alternative to age-fighting retinol, without having any of the negative side effects like irritation or sensitivity associated with retinol.
Retinol is renowned for its all-around anti-aging and acne-fighting abilities. But many people find retinol’s side effects (irritation, dryness, peeling, erythema, burning) to be unacceptable, and these side effects often result in non-compliance and discontinuation of therapy.
That’s where Revivinol comes to the rescue.
Revivinol’s dual action components, Sytenol (R) A and Dermapep (tm) A350, are powerful substitutes for retinol and retinoic acid without the negative side effects, and are supported by strong efficacy data shown to help reverse the appearance of wrinkles, mottled hyperpigmentation, and age-related changes. Its retinol-like activity helps support skin’s natural collagen synthesis and an anti-aging effect against environmental stimulus like UV irradiation. Great for all skin types, even sensitive, it does not irritate or make skin photosensitive like retinoids, so it may be used during the day.
Revivinol Serum also targets damaging UV, infra-red, and blue light radiations from phones, tablets and computers, as well as pollutants in the air, with the remarkable compound LUMICEASE BLUE.
Here’s a short video: https://www.youtube.com/watch?v=TdpRvOg1N2s
“As the first company worldwide to bring such a product to market, we are delighted to augment our popular and superbly effective range of skincare serums with such a remarkable ‘unretinol’ product,” noted Vance Nesbitt, Reviv Serums’ ”Director of Lotions and Potions” and principal formulator. “Revivinol Serum is also packed with a deep hydration active that lasts an amazing 72 hours, and a biomimetic peptide based on a sea anemone protein which reduces the appearance of skin irritation and redness.”
Revivinol “Unretinol” Serum is available immediately at RevivSerums.com here, which ships to many countries worldwide with free shipping, and at select retailers, e-tailers, salons, medspas and physician’s offices.
Its release coincides with Indie Beauty Expo Los Angeles, the biggest independent beauty trade event in the world.
#Revivinol #RevivSerums #SytenolA #retinol #retinoids #bakuchiol #weareindiebeauty
Revivinol is a trademark of Astonishing Developments Ltd. Sytenol is a registered trademark of Sytheon Ltd. DermaPep is a trademark of Miwon Commercial Co., Ltd. LUMICEASE is a trademark of Lipotec S.A. Other company and/or product names may be trade names, trademarks and/or registered trademarks of the respective owners with which they are associated. These statements have not been evaluated by the U.S. Food and Drug Administration. Products not intended to diagnose, treat, cure, or prevent any disease. Products described are intended to meet the FDA’s definition of a cosmetic product, an article applied to the human body to cleanse, beautify, promote attractiveness, and alter appearances.
About RevivSerums.com / Astonishing Developments Ltd.
RevivSerums.com, based in beautiful San Francisco, specializes in novel and innovative clinical treatment serums for skin and hair rejuvenation. Their unique formulations are next-generation, high-performance, leading-edge — and any other great hyphenated catchphrases you can imagine.
[Spoiler Alert: Our Phloretin Ferulic Serum DIY Kit with 20% L-Ascorbic Acid has it, and is a great value!]
Vitamin C: You know it’s—spoiler alert—a vitamin, you probably reach for it when you’re starting to feel a cold coming on, and chances are, you may have dabbled with a drop or two of it in your skin care at some point. So why is this standard ingredient that’s kind of always around not always applauded for all the many things it does? “It’s definitely an underrated and unsung ingredient that people think is passé,” says New York dermatologist Dennis Gross, MD, who is launching a new line devoted completely to the ingredient this week. “But it’s been reengineered and advanced and it’s more important than ever for anyone who wants to have beautiful, younger-looking skin. It’s part of the magic potion—it is such a powerful anti-ager with a broad spectrum of benefits.”
Benefit #1: It’s an Antioxidant A-Lister
Vitamin C is an antioxidant, an often-thrown-around term that sounds good, but not always totally straightforward to understand in relation to aging and the skin. To break it down, New York dermatologist Dendy Engelman, MD, says to look at antioxidants as “skin protectors.” They fight against free-radical assaults (things like UV rays, sun exposure, pollution and cigarette smoke) by neutralizing oxidative stress that causes cell damage, which, in excess and over time, results in signs of aging. “Free-radical scavengers are in search of a missing electron. Antioxidants like vitamin C neutralize the damage by donating their electron, thus minimizing the damage a free radical can do on skin proteins such as collagen or elastin,” she says, adding that the more antioxidants present in skin, the less damage free radicals can inflict, which is directly tied to better skin health and a more youthful appearance.
Benefit #2: It’s a Collagen-Booster
Perhaps the most unique benefit of vitamin C is the fact that it has the ability to boost collagen. “We talk about lines, wrinkles, laxity, loose skin, crow’s-feet. All of those things boil down to collagen—it is the holy grail of youth,” Dr. Gross says. “It’s a structural protein in the skin that gives it its firmness. You have an abundance of it when you are younger, but you lose it as you age and that’s what leads to those lines and wrinkles. Vitamin C stimulates collagen—it works on the cells in the skin that have become lazy with age and tells them to make more collagen.” As he also stresses, vitamin C is the only collagen stimulator that can boast of having antioxidant properties. “So it’s not only simulating your own collagen, but it’s protecting it as well.”
Benefit #3: It Can Help With Pores
Dr. Gross says you can scrub until “the cows come home,” but most products won’t do much to help with the appearance of your pores. “Pores can look large because of the collagen loss. By stimulating collagen and thickening your skin, vitamin C can help pores look smaller and better.”
Benefit #4: It’s a Big-Time Skin Brightener
In addition to protecting against UVA/UVB exposure, vitamin C also lightens pigmentation and brightens skin tone. “It works directly on the mechanism that causes uneven skin tone—sun spots, melasma, hyperpigmentation; all those things that cause uneven color in your skin,” Dr. Gross says. Plus, as Dr. Engelman points out, you can safely wear it during the day and add it to your normal nighttime regimen. Her tip: Start young with a moisturizer containing an antioxidant complex, such as vitamin C. (She recommends Nerium Age-Defying Day Cream, AD Formula, Skinceuticals C E Ferulic and Nerium Age-Defying Eye Serum.)
Benefit #5: It’s Potent When Applied to Skin
As Dr. Gross explains, when you apply vitamin C to your skin, it’s a lot more concentrated of a dosage when compared to taking it orally. “It is so much stronger when applied directly. You would have to take so many milliliters of vitamin C orally to actually reach your skin that you would get sick. Topical application of vitamin C is so much more powerful in terms of what it’s going to do for your skin.”
Benefit #6: It Pairs Nicely With Retinol
The bottom line: “Vitamin C and retinol are two gold standards for skin care,” says Dr. Engelman, adding that they both do different things. “While both reduce signs of aging, vitamin C acts as a protector for your skin and neutralizes issues before there is a problem and improves current skin conditions. Retinols act as an ‘exfoliating’ tool to rid the skin of damaged cells and stimulate production.” Adds Dr. Gross, “Retinol is not like vitamin C. It’s not an antioxidant and it’s not a direct stimulator of collagen. I recommend using both.”
— Reprinted/excerpted from New Beauty Magazine http://ow.ly/3EFs307HrlR
Terrific reviews of new TelomErase 6-in-1 Multi-Corrective Serum continue to flow in as word spreads. Beauty bloggers LOVE the new product. Here's a compendium of the latest review site posts:
http://www.venuslovesvirgo.com/2015/11/telomerase-triple-telomere-targeting.html http://www.angiewagg.com/2015/11/telomerase-serum-triple-telomere.html https://lifestylebites3.wordpress.com/2015/11/11/review-reviv-serums-telomerase-serum http://glamamamasgoodies.blogspot.com/2015/11/telomerase-serum-triple-telomere.html http://www.hannamarielei.com/2015/11/telomerase-serum-review-triple-telomere.html http://feastyoureyesonthis.weebly.com/katelyns-blog/telomerase-serum-review#comments
Ultimate Serum is the first direct competitor to award-winning TNS Essential Serum® (NEWBEAUTY™ Beauty Choice Award Winner and InStyle™ Beauty Award Winner) by SkinMedica® which is now owned by Allergan, Inc. The patent on the TNS product relates to the medium called NouriCel-MD®, a "proprietary blend" of growth factors. We at Reviv Serums outflank this patent by simply providing our growth factors in a different conditioned media. In addition to the growth factors, we also include 42 of the top primary ingredients in TNS Essential Serum, and leapfrog by adding two of cosmetic chemistry's latest ingredients: stem cells and hexapeptides.
With our latest version of Ultimate Serum, we've added 10+ primary actives from SkinMedica's "upgrade" to TNS Essential Serum, TNS® Advanced +.
Ultimate Serum is 70% larger than either TNS product (50 mL / 1.69 FL OZ vs. 1.0 OZ) and yet is just about a third of the cost of TNS Essential Serum's hefty price of $281.00 and TNS Advanced Plus' $295.00.
It’s the ultimate rejuvenator in a single serum. Navigate to its product page here.