Making Hair Loss History: Native Polyphenols to Kick-start Hair Regrowth

Treating alopecia with RevivHair Hair Stimulating Serum & Redensyl

A new study of the patented molecules in our Redensyl® ingredient confirm its remarkable role in hair stimulation and hairloss prevention. 

Redensyl is not the only ingredient that makes RevivHair Max Hair Stimulating Serum so remarkably effective — our novel growth factors, stem cells, and peptides combine to make it a powerhouse. But Redensyl is undoubtedly a big hero in our hero serum.

Excerpts from the study:

Results: Clinical Studies

It is well-known that the growth of scalp hair is a cyclical process, made up of successive phases of growth (anagen) and rest (telogen).11, 20 In a non-balding scalp, more than 90% of scalp hair is in an anagen phase.12

However, with AGA [Androgenic Alopecia], the progressive shortening of the anagen phase, as well as an increase in the duration of the lag phase (i.e., the interval between the shedding of a telogen hair and the emergence of a replacement anagen hair), across successive hair cycles, progressively decreases the percentage of hair follicles in the anagen phase. For men with male pattern hair loss, only 60% to 80% of total hairs are in anagen phase. This shortening of the anagen phase leads to progressive miniaturization of hair follicles, which contributes to a decrease of visible hair over affected areas of the scalp.13

In the present clinical study, the authors demonstrated that treatment with DEGZ [Redensyl] 3% for three months daily efficiently treats androgenetic alopecia by increasing the percentage of hair in the anagen phase (by about +9%) and decreasing the percentage of hair in telogen phase (by about -17%) (see Table 1). In this study, an insignificant placebo effect also was observed, likely due to the mechanical activation of microcirculation, with almost no more evolution after one month.

None of the results obtained with the placebo were statistically significant. However, 3% DEGZ increased the density ratio of hair in the anagen phase to hair in the telogen phase. After three months, the ratio reached 2.37 (+29%) while the placebo showed no evolution after one month (see Table 2). Furthermore, this hair density increase observed after three months of treatment was confirmed by the scalp’s macrophotography (see Figure 6).

At the end of the study, volunteers using the test DEGZ formula judged their hair as stronger and thicker (data not shown). These benefits are likely provided by the glycine and zinc in the test blend. Glycine is an essential component for the hair shaft structure that directly enters hair’s composition of keratin-associated protein.14 Zinc reinforces hair shaft structure and is essential for cystin incorporation into keratin.15

Conclusion

DHQG and EGCG2 are two glucosylated derivatives of native dihydroquercetin and epigallocatechin gallate. These two polyphenols were previously shown to have different properties for hair care.7, 16

The present studies demonstrate that when these two molecules are used alone or in combination, beneficial properties are observed; including HFDPc metabolism stimulation, ORSc proliferation, beta catenin activation and anti-apoptotic effects on ORSc. In combination with EGCG2, and glycine and zinc, DHQG also induced the growth of AGA hair follicle explants cultured in vitro according to the Philpott model. This study also confirmed the crucial role of EGCG2 in hair growth induction.

Clinical investigations described here show this blend can treat androgenic alopecia by re-launching hair growth pathways and visibly decreasing hair loss within three months by promoting the conversion of hair follicles into the anagen phase via the activation of Wnt/β-catenin pathway, and by limiting the apoptosis of ORSc. Finally, the efficiency of the test blend as an alopecia hair loss treatment was confirmed by a high user satisfaction rate (+71%) during the clinical investigation.

- See more at: http://www.cosmeticsandtoiletries.com/testing/efficacyclaims/Making-Hair-Loss-History-Native-Polyphenols-to-Kick-start-Hair-Regrowth-425945524.html

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RevivSerums.com Launches First Swiss Hair Stimulating Redensyl Product in U.S.


FOR IMMEDIATE RELEASE
Contact: Bill Henderson
Email: pressrelations@revivserums.com
Phone: (415) 763-7248

RevivSerums.com Launches First Swiss Hair Stimulating Redensyl Product in U.S.

SAN FRANCISCO, JULY 31, 2014 /PRNewswire/ – RevivSerums.com is the first North American company to bring a hair care product to market containing award-winning Redensyl® from Swiss-based Induchem®.

Designed for both men and women, this novel next-generation leave-in serum can help significantly boost hair density, thickness, fullness, natural color, strength, and overall health.

"We are delighted to be one of the first to bring Redensyl to market, and to augment our popular and effective hair stimulating serum with this unique active," said Astonishing Developments' Director of Lotions and Potions Vance Nesbitt and principal formulator. "In updating one of our most popular products, we make it even more potent and effective while still maintaining its current price point of $49 (a $100 value). And with the addition of new polymers, it is even better for daily use since it instantly strengthens and thickens existing hair without making the hair stiff, oily, or smelly."

Induchem, creator of Redensyl, is a leading Swiss producer of specialty cosmetic actives for the personal care and cosmetic industry, with a worldwide presence including U.S.-based Induchem USA, Inc. in New York City. 

"As we further build our premier global brand in clinically proven personal care ingredients, we are excited about the continued growth potential in the U.S. market for us and for RevivSerums,” said Induchem U.S.A.'s General Manager Parand Salmassinia. "We're looking forward to a very productive working relationship that will benefit customers across the nation.”

Award-Winning 

Redensyl won In-Cosmetics 2014 Silver Award for Best Ingredient at its annual global showcase for personal care ingredients in Hamburg this past spring (http://www.induchem.com/news-home/redensyl-silver-award-at-in-cosmetics-2014/). 

Induchem cites Redensyl to be "the first cosmetic alternative to hair transplantation surgery." The product combines two patented Induchem molecules - DHQG and EGCG2 - to reactivate hair growth by targeting hair follicle stems cells, reactivating the proliferation of ORSc stem cells, protecting them from apoptosis, maintaining their differentiation properties, and activating the metabolism of dermal papillary fibroblasts.

Induchem's clinical assessment on volunteers produced outstanding results for Redensyl. In less than three months, 85 percent of the volunteers had significant and visible hair growth, with +9 percent of new growing hair and -17 percent of falling hair, enabling up to +28,200 new hairs in 84 days.

Redensyl yields almost two times the score of the worldwide reference minoxidil, according to Induchem.

Effective Ingredients 

RevivSerums is now incorporating this innovative, award-winning product in a new formulation of its popular 5 star-reviewed RevivHair Stimulating Serum.

In addition to the incorporation of Redensyl, RevivSerums is updating its hair stimulating serum with several additional new breakthrough ingredients:

• PhytoCellTec™ Argan, from Swiss-based Mibelle AG Biochemistry, is the first cosmetic active with proven efficacy on dermal stem cells. Hair follicles represent a highly relevant and efficient penetration pathway and reservoir for topically applied substances. Dermal papilla, where the dermal stem cell pool is localized, can be reached over follicular penetration. Sox2 expression is enhanced and “stemness” of the dermal stem cells is improved which in turn induces the repair of hair follicles.

• Cellulosomes® Crithmum Maritimum ST from Seppic® is an exclusive Sea Fennel stem cell culture that helps promote better epidermal metabolism, increases cell renewal, and the synthesis of collagen, proteoglycans, and glycosaminoglycans.

In addition to these breakthrough new ingredients, RevivHair Stimulating Serum contains its armament of remarkably effective, novel actives:

• Human Keratinocyte Growth Factor (KGF, rh-Polypeptide-3); PhytoCellTec™ Malus stem cells; Prezatide Copper Acetate; Myristoyl Pentapeptide-17; Copper Tripeptide-1; Acetyl Tetrapeptide-3; Biotinoyl Tripeptide-1; Palmitoyl Tripeptide among other superb actives.

The revised formula is now fragrance-free, and its base is a light, almost clear, formulation safe for all hair colors and hair types.

In addition to these innovative new ingredients, Reviv Serums is now providing PDPO (Pyrrolidinyl Diaminopyrimidine Oxide -- trade name Triaminodil™) in a separate optional vial for customers who want the growth-regulating effects similar to its chemical cousin minoxidil, which is a Pyrimidinediamine Piperidinyl Oxide. The vial ingredient is optional for those users who don't mind potential initial increased shedding since this ingredient can help promote the transition from the telogen (resting) phase to the anagen (growing) phase of the hair cycle. The vial is a customer add-on, and is only $5.

Revivair Stimulating Serum is meant to be used once or twice daily in addition to regular styling products or products such as minoxidil, and is applied directly to the scalp. 

Note: The serum is considered a cosmetic, not a drug, and the product is not intended for use in the cure, mitigation, treatment, or prevention of disease and/or is not intended to affect the structure or any function of the human body.

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Quick Links

Social Media
#RevivSerums  #Redensyl  #Induchem  #hairloss  #hairgrowth

Product Packaging Photos
600 x 600 px (with "Indiglo" filter):  http://bit.ly/1mJqQ7r
4000 x 3000 px:  http://bit.ly/1nlamaF
1200 x 1200 px:  http://bit.ly/1jXGTDI

Graphics
RevivSerums logo file (black background): http://bit.ly/1l8RCqo
RevivSerums logo file (white background):  http://bit.ly/1x7nvou
Redensyl Silver Award Seal from in-Cosmetics:  http://bit.ly/1rDWKdi

Brochures
Redensyl Brochure:   http://bit.ly/1ke5YLe
PhytoCellTec Argan:  http://bit.ly/1rPeMXx
PhytoCellTec Malus:  http://bit.ly/1tGoITM
Cellulosomes Crithmum Maritimum ST:  http://bit.ly/1nXYjLH

Videos
PhytoCellTec™ Argan stem cells: https://www.youtube.com/watch?v=piwFnNY432U
PhytoCellTec™ Malus stem cells: https://www.youtube.com/watch?v=CnrQ7owWapQ

Company Websites
About RevivSerums.com
RevivSerums.com is a wholly owned component of Astonishing Developments Ltd., based in San Francisco, California. The company specializes in novel and innovative clinical treatment serums for skin and hair rejuvenation. They currently distribute throughout North America (U.S., Canada, Mexico), Europe and South Africa and are poised to enter markets in Japan.

Legal
RevivSerums is a trademark of Astonishing Developments Ltd. Redensyl is a registered trademark of Induchem Holding AG Corporation, Switzerland. Other company and/or product names may be trade names, trademarks and/or registered trademarks of the respective owners with which they are associated.

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Head To Head Comparison: Ultimate Serum™ vs. SkinMedica® TNS Essential Serum®

Ultimate Serum "Compare To" product to TNS Essential Serum from SkinMedica | Larger, Cheaper, 23 same ingredients

Ultimate Serum
is the first direct competitor to award-winning TNS Essential Serum® (NEWBEAUTY™ Beauty Choice Award Winner and InStyle™ Beauty Award Winner) by SkinMedica® which is now owned by Allergan, Inc. The patent on the TNS product relates to the medium called NouriCel-MD®, a "proprietary blend" of growth factors. We at Reviv Serums outflank this patent by simply providing our growth factors in a different conditioned media. In addition to the growth factors, we also include 42 of the top primary ingredients in TNS Essential Serum, and leapfrog by adding two of cosmetic chemistry's latest ingredients: stem cells and hexapeptides.

Regarding the percentage of growth factors in each product: In actuality, the growth factors in both products are quantities measured in micrograms. TNS just lists "conditioned media" as the first ingredient, and does not break down the quantities of the actual factors like EGF, KGF, VEGF, IGF, TGF, etc. Growth factors are signaling molecules, therefore very little volume/quantity is required to be active and effective (they are measured in micrograms, one millionth of a gram). Like a spark plug, a little bit will go a very long way, and more that the recommended quantity is not "better." As for the other non growth factor primary ingredients, they're the same - plus we add the PhytoCellTec® Stem Cells, hexapeptides, SYN-TC peptides, and microbiome probiotic technology. Ultimate Serum is 70% larger than TNS (50 mL / 1.69 FL OZ vs. 1.0 OZ) and yet is less than half TNS's hefty price of $281.00.

Ultimate Serum contains a safe Ecocert preservative — Optiphen Plus.

Ultimate Serum is really 11 different products in one:

 

• A brightening product
• An antioxidant serum
• A firming and tightening product
• An anti-inflammatory
• A peptide serum
• A green tea complex product
• A vitamin C serum
• A sebum controller
• A collagen stimulator serum
• A growth factor serum
• A moisturizer and light emollient

 

It’s the ultimate rejuvenator in a single serum. Navigate to its product page here.

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