Can Skincare Improve Your Overall Health?

Woman face hydration orchid serum

According to researchers
 at the University of California, San Francisco (UCSF), and the San Francisco Veterans Administ­ration Health Care System (SFVA), moisturized skin might prevent age-related ailments including Alzheimer's, heart disease and diabetes.

The cosmetic and personal care industry hears it all the time: the skin is the body’s largest organ; and we focus on its holistic status to treat signs of aging, or address compromised conditions. But what we do not often consider is how its negative health could affect our overall health—being the largest organ. A new pilot study from dermatol­ogists at UCSF and the SFVA brings this perspective to light.

Inflammation, Aging and the Skin

According to the researches, as humans age, low levels of inflammation—or inflammaging—occur, driven by an increase in molecules in the blood known as cytokines. Such age-related inflammation has been linked to chronic diseases including Alzheimer’s, cardiova­scular disease and diabetes. And while scientists suspected the inflammation stemmed from the immune system or liver, this group of dermatol­ogists have a different theory.

“The inflammation must come from an organ big enough that very minor inflammation can affect the whole body," explained study senior author Mao-Qiang Man, M.D, a research scientist in the UCSF, based at the SFVA Health Care System, who is also a visiting professor at Southern Medical University in Guangzhou, China. "Skin is a good candidate for this because of its size.”

While ordinarily, cytokines help to repair defects in the barrier; but in aging skin, the barrier is not so easily repaired, and inflammatory signals continue to be released, eventually reaching the blood.

Man added that with aging, dermatol­ogical symptoms such as itchiness, dryness and changes in acidity arise. So while skin may have minor inflammation, due to its relative size to the body, this elevates circulating cytokine levels. Furthermore, skin starts to deteriorate at around the age of 50, with changes to epidermal pH, hydration and the permeability barrier; and a loss in moisture or breaks in the permeability barrier also can cause the skin to release inflammatory cytokines.

While ordinarily, cytokines help to repair defects in the barrier, in aging skin, the barrier is not so easily repaired, so the inflammatory signals continue to be released, eventually reaching the blood.

“Until recently, the scientific community didn’t believe that skin could contribute to systemic inflammation and disease," said study lead author Theodora Mauro, M.D, a professor of dermatology at UCSF and the SFVA Health Care System. "But in the last five years, studies of psoriasis and dermatitis have shown that skin inflammation from these diseases likely increases the risk of heart disease."

Topical Treatment

Based on these and other observations, the researchers published a study in the Journal of the European Academy of Dermatology and Venereology, whereby they attempted to reverse age-related skin damage using an over-the-counter skin cream formulated with cholesterol, free fatty acids and ceramides, which had previously been shown to contribute to skin repair.

Using the cream reportedly lowered participants’ cytokine levels to be nearly equivalent with people in their 30s.

Thirty-three older adults between the ages of 58 and 95 years applied the cream all over their bodies twice daily for 30 days. After one month, the researchers measured blood levels of three cytokines—interleukin-1 beta, interleukin-6, and tumor necrosis factor (TNF) alpha—all of which have been implicated in age-related inflammatory diseases.

Use of the cream reduced the amount of all three cytokines, compared with both the participants’ levels before application of the cream and the levels of similarly aged adults who did not use the cream. In fact, using the cream reportedly lowered participants’ cytokine levels to be nearly equivalent with people in their 30s.

“We're going to see whether using the cream to keep epidermal function normal as people age will prevent the development of those downstream diseases,” said co-author Peter Elias, M.D., a UCSF professor of dermatology based at the SFVA Health Care System. “If we do, the implication would be that after the age of 50, you would want to be applying an effective topical barrier repair preparation daily for the rest of your life.”

— Reprinted/excerpted from Cosmetics & Toiletries® Magazine

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Beauty Influencer Evaluates Revivinol "Unretinol" Serum

Before and after photos of alt-Retinol product cheaper bigger better than Biossance Squalane + Phyto-Retinol Serum

Beauty Influencer @bawbby_ reviews new Revivinol Serum, the first dual powerhouse natural alternative to retinol — without the downsides!

“I just finished my 10th use of Revivinol Serum and I couldn’t wait to finally share my thoughts! My main area of concern was this horrible breakout of red bumps I’ve had on my forehead for TWO YEARS. Nothing I tried would fix it, so I covered it with makeup and airbrushing for photos. But after 10 days with this serum, the bumps are GONE and my skin tone has even improved! My entire face looks and feels the best it has in years. I am completely blown away, I thought nothing would ever work for my stubborn skin! I am being 100% honest when I tell you this serum has changed my life. I feel 110% more confident without those unsightly bumps and my red patches.

…this serum is truly amazing and I will continue faithfully using it and recommending it to EVERYONE. Nothing in my life has ever worked as well on my problematic skin as this serum!”

Get Revivinol Serum, a full 2 ounces in size, at a great price here at RevivSerums.com


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All about Fluidipure 8G in RevivScalp and RevivHair Stimulating Shampoo

Flaking and oiliness addressed with Fluidipure 8G

FluidiPure 8G is a biomimetic purifying active agent which offers complete protection for the body’s “cutaneous cocoon.” As a glycine and sugar “biovector,” FluidiPure 8G helps to limit the proliferation of microorganisms responsible for cutaneous disorders. Its biomimetic acidifying power helps attacked skin to regain its physiological acidic pH, ensuring its integrity.

When tested in vivo on hair, it reduces the appearance of dandruff, soothes the scalp and eliminates unpleasant odors after 5 and 10 shampoos (clinical study performed on 46 volunteers vs. placebo).

On skin, FluidiPure 8G participates in reducing unpleasant scalp odors while it helps preserves bacteria beneficial to the skin and restore the skin’s natural acidic pH mantle, also helping to reduce skin sensitivity.

FluidiPure 8G also reduces the effects of 5-alpha reductase by 18% compared to a control, helping to regulate sebum and the reduction of hair loss.

Get these remarkable benefits in both RevivScalp Rejuvenating Scalp Serum Masque and RevivHair Stimulating Shampoo.


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All About Hyaluronic Acid

Written By: The Serum Guru

Hyaluronic acid is a key ingredient in every one of our facial serums. Read about its very novel features, especially that despite its large molecule size, a study shows that surprisingly it actually penetrates deep into the epidermis, the dermis and the lymphatic endothelium.

From our colleagues over at the The Beauty Brains, full details:

http://thebeautybrains.com/2015/03/24/is-hyaluronic-acid-a-good-anti-aging-ingredient/

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